R
Riley C. Myers
Researcher at University of Alabama at Birmingham
Publications - 5
Citations - 832
Riley C. Myers is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Germinal center & Follicular dendritic cells. The author has an hindex of 5, co-authored 5 publications receiving 787 citations.
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Journal ArticleDOI
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Hui-Chen Hsu,PingAr Yang,John H. Wang,Qi Wu,Riley C. Myers,Jian Chen,John S. Yi,Tanja Guentert,Albert Tousson,Andrea L Stanus,Thuc-vy L. Le,Robin G. Lorenz,Hui Xu,Jay K. Kolls,Robert H. Carter,Robert H. Carter,David D. Chaplin,Robert W. Williams,John D. Mountz,John D. Mountz +19 more
TL;DR: It is demonstrated that autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production of pathogenic autoantibodies, suggesting a mechanism by which IL- 17 drives autoimmune responses by promoting the formation of spontaneous GCs.
Journal ArticleDOI
Marginal Zone B Cells Regulate Antigen Capture by Marginal Zone Macrophages
Yuying You,Riley C. Myers,Larry E. Freeberg,Jeremy B. Foote,John F. Kearney,Louis B. Justement,Robert H. Carter +6 more
TL;DR: It is demonstrated that SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO)+ macrophages that is diminished when MZ B cells are absent due to either genetic developmental defects or following transient migration of B cells out of the MZ.
Journal ArticleDOI
Germinal center structure and function: lessons from CD19.
Robert H. Carter,Riley C. Myers +1 more
TL;DR: Structural findings indicate a selective role in the interaction with follicular dendritic cells in the GC, and loss of these signals leads to surprising changes in germinal center B cells that challenge previous models of GC function.
Journal ArticleDOI
Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response.
TL;DR: Recruitment of CD19+ wild‐type B cells into CD19‐deficient hosts rescued GC formation and FDC activation, demonstrating that CD19 expression on B cells is required for FDCactivation.
Journal ArticleDOI
STAT4-Dependent and -Independent Th2 Responses Correlate with Protective Immunity against Lung Infection with Pneumocystis murina
TL;DR: The data suggest that robust local and systemic Th2-mediated responses are critical for immunity to Pneumocystis.