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Qi Wu
Researcher at University of Alabama at Birmingham
Publications - 37
Citations - 2096
Qi Wu is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: B cell & Cytotoxic T cell. The author has an hindex of 22, co-authored 37 publications receiving 1952 citations.
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Journal ArticleDOI
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Hui-Chen Hsu,PingAr Yang,John H. Wang,Qi Wu,Riley C. Myers,Jian Chen,John S. Yi,Tanja Guentert,Albert Tousson,Andrea L Stanus,Thuc-vy L. Le,Robin G. Lorenz,Hui Xu,Jay K. Kolls,Robert H. Carter,Robert H. Carter,David D. Chaplin,Robert W. Williams,John D. Mountz,John D. Mountz +19 more
TL;DR: It is demonstrated that autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production of pathogenic autoantibodies, suggesting a mechanism by which IL- 17 drives autoimmune responses by promoting the formation of spontaneous GCs.
Journal ArticleDOI
IL-17 Activates the Canonical NF-κB Signaling Pathway in Autoimmune B Cells of BXD2 Mice To Upregulate the Expression of Regulators of G-Protein Signaling 16
Shutao Xie,Jun Li,John H. Wang,Qi Wu,PingAr Yang,Hui-Chen Hsu,Lesley E. Smythies,John D. Mountz,John D. Mountz +8 more
TL;DR: It is found that IL-17 rapidly activates the canonical NF-κB signaling pathway and that BXD2 B cells exhibit higher basal and activated phosphorylated p65 levels than B6 or BxD2-Il17ra−/− B cells.
Journal ArticleDOI
Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.
Yanna Ding,Jun Li,PingAr Yang,Bao Luo,Qi Wu,Allan J. Zajac,Oliver Wildner,Hui-Chen Hsu,John D. Mountz +8 more
TL;DR: This study was undertaken to determine the modulatory effects of IL‐21 on Tfr cells and the Tfr cell to Tfh cell balance in BXD2 mice and it was shown that interleukin‐21 promoted T fh cell differentiation in autoimmune BXd2 mice that develop spontaneous GCs.
Journal ArticleDOI
Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5).
Kurt R. Zinn,Joanne T. Douglas,Cheryl A. Smyth,Hong-Gang Liu,Qi Wu,Victor Krasnykh,John D. Mountz,David T. Curiel,James M. Mountz +8 more
TL;DR: In vivo dynamic imaging with an Anger gamma camera revealed that the liver binding followed an exponential rise to maximum, with a measured 100% extraction efficiency, and demonstrated that in vivo imaging is a sensitive tool for measuring changes to liver tropism.
Journal ArticleDOI
IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells
Yanna Ding,Jun Li,Qi Wu,PingAr Yang,Bao Luo,Shutao Xie,Kirk M. Druey,Allan J. Zajac,Hui-Chen Hsu,John D. Mountz,John D. Mountz +10 more
TL;DR: It is suggested that TFH differentiation and its stabilization in the LZ are two separate checkpoints and that IL-21 and IL-17 act at each checkpoint to enable pathogenic GC development.