R
Risa Imaizumi
Researcher at Toho University
Publications - 4
Citations - 229
Risa Imaizumi is an academic researcher from Toho University. The author has contributed to research in topics: Fibroblast & Basic fibroblast growth factor. The author has an hindex of 4, co-authored 4 publications receiving 206 citations.
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Journal ArticleDOI
Basic fibroblast growth factor in an artificial dermis promotes apoptosis and inhibits expression of α-smooth muscle actin, leading to reduction of wound contraction
Yoshikiyo Akasaka,Ichiro Ono,Akihiro Tominaga,Yukio Ishikawa,Kinji Ito,Takeya Suzuki,Risa Imaizumi,Shigeki Ishiguro,Kowichi Jimbow,Toshiharu Ishii +9 more
TL;DR: Results suggest that bFGF administration to an artificial dermis promotes apoptosis of α‐SMA‐positive fibroblastic cells and inhibits α‐ SMA expression in the treated wound, thus reducing wound contraction.
Journal ArticleDOI
Basic fibroblast growth factor induces down‐regulation of α‐smooth muscle actin and reduction of myofibroblast areas in open skin wounds
Shigeki Ishiguro,Yoshikiyo Akasaka,Hideko Kiguchi,Takeya Suzuki,Risa Imaizumi,Yukio Ishikawa,Kinji Ito,Toshiharu Ishii +7 more
TL;DR: BFGF is identified as a potent stimulator for the reduction of the myofibroblastic area in vivo, presumably because of its effects on the down‐regulation of α‐SMA expression as well as rapid induction of apoptosis in myofIBroblasts.
Journal ArticleDOI
Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression
Risa Imaizumi,Yoshikiyo Akasaka,Naomi Inomata,Emi Okada,Kinji Ito,Yukio Ishikawa,Yu Maruyama +6 more
TL;DR: The aim was to investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitor of met alloproteinase (TIMPs) in pathological wound healing in keloids.
Journal ArticleDOI
The mechanisms underlying fibroblast apoptosis regulated by growth factors during wound healing.
Yoshikiyo Akasaka,Ichiro Ono,Takafumi Kamiya,Yukio Ishikawa,Toshio Kinoshita,Shigeki Ishiguro,Tomoko Yokoo,Risa Imaizumi,Naomi Inomata,Kazuko Fujita,Yuri Akishima-Fukasawa,Miwa Uzuki,Kinji Ito,Toshiharu Ishii +13 more
TL;DR: A significant role for the two cytokines in apoptosis of granulation tissue fibroblasts during wound healing is demonstrated, with a marked decline in phosphorylation and protein expression of Akt and FAK in bFGF‐injected skin wounds.