R
Rishabh K. Simhal
Researcher at Duke University
Publications - 27
Citations - 119
Rishabh K. Simhal is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 64 citations.
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Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.
Xiangyu Liu,Ali Masoudi,Alem W. Kahsai,Li-Yin Huang,Biswaranjan Pani,Dean P. Staus,Paul J. Shim,Kunio Hirata,Rishabh K. Simhal,Allison M. Schwalb,Paula K. Rambarat,Seungkirl Ahn,Robert J. Lefkowitz,Robert J. Lefkowitz,Brian K. Kobilka,Brian K. Kobilka +15 more
TL;DR: The crystal structure of the prototypic β 2 -adrenergic receptor in complex with an orthosteric agonist and compound-6FA, a positive allosteric modulator of this receptor is reported, revealing a pocket created by intracellular loop 2 and transmembrane segments 3 and 4, stabilizing the loop in an α-helical conformation required to engage the G protein.
Journal ArticleDOI
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
Seungkirl Ahn,Biswaranjan Pani,Alem W. Kahsai,Eva Kampmann Olsen,Gitte Nystrup Husemoen,Mikkel Vestergaard,Jin Lei,Shuai Zhao,Laura M. Wingler,Paula K. Rambarat,Rishabh K. Simhal,Thomas T. Xu,Lillian D. Sun,Paul J. Shim,Dean P. Staus,Li-Yin Huang,Thomas Franch,Xin Chen,Robert J. Lefkowitz +18 more
TL;DR: The first β2AR small-molecule positive allosteric modulators (PAMs) are discovered and characterized using the recently developed approach for screening G protein–coupled receptors (GPCRs) with DNA-encoded small- molecule libraries, and introduced.
Journal ArticleDOI
Gender Diversity in Urology Residency Program Leadership Is Associated with Gender Diversity in Residency Cohort.
Rishabh K. Simhal,Y. Shah,Kerith Wang,Sohan Shah,Maria J D'Amico,Joon Yau Leong,Costas D. Lallas,Patrick J. Shenot,Mihir S Shah,Alana M. Murphy +9 more
TL;DR: The authors evaluated the association of program director gender on the proportion of female residents in urology residency programs and found that programs with female PDs were more likely to match female residents, whether those programs had female leadership rank female applicants more favorably or female applicants rank those programs higher.
Mp56-18 stent vs stent-less ileal conduits after radical cystectomies: is there difference in early postoperative outcomes
Rishabh K. Simhal,Yash Shah,Kerith Wang,Daniel P Simon,James Ryan Mark,Zachary J. Prebay,Costas D. Lallas,Leonard G. Gomella,Mihir S Shah +8 more
TL;DR: In this paper , there was no sign of any difference in 30-day rates of UTIs, AKIs, renal failure, anastomotic leaks, ureteral obstruction and stula formation.
Journal ArticleDOI
Bladder diverticulum caused by primary bladder neck obstruction
TL;DR: A case of a patient in their mid 30s who presented with an elevated creatinine and was found to have a massive bladder diverticulum and underwent robotic-assisted diverticulectomy, leading to significant improvement in urinary symptoms.