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Rishabh K. Simhal

Researcher at Duke University

Publications -  27
Citations -  119

Rishabh K. Simhal is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 64 citations.

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Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.

TL;DR: The crystal structure of the prototypic β 2 -adrenergic receptor in complex with an orthosteric agonist and compound-6FA, a positive allosteric modulator of this receptor is reported, revealing a pocket created by intracellular loop 2 and transmembrane segments 3 and 4, stabilizing the loop in an α-helical conformation required to engage the G protein.
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Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.

TL;DR: The first β2AR small-molecule positive allosteric modulators (PAMs) are discovered and characterized using the recently developed approach for screening G protein–coupled receptors (GPCRs) with DNA-encoded small- molecule libraries, and introduced.
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Gender Diversity in Urology Residency Program Leadership Is Associated with Gender Diversity in Residency Cohort.

TL;DR: The authors evaluated the association of program director gender on the proportion of female residents in urology residency programs and found that programs with female PDs were more likely to match female residents, whether those programs had female leadership rank female applicants more favorably or female applicants rank those programs higher.

Mp56-18 stent vs stent-less ileal conduits after radical cystectomies: is there difference in early postoperative outcomes

TL;DR: In this paper , there was no sign of any difference in 30-day rates of UTIs, AKIs, renal failure, anastomotic leaks, ureteral obstruction and stula formation.
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Bladder diverticulum caused by primary bladder neck obstruction

TL;DR: A case of a patient in their mid 30s who presented with an elevated creatinine and was found to have a massive bladder diverticulum and underwent robotic-assisted diverticulectomy, leading to significant improvement in urinary symptoms.