Biswaranjan Pani

TL;DR: This work has used a variety of biochemical, biophysical, and cell-based methods to demonstrate the existence, functionality, and architecture of internalized receptor complexes composed of a single GPCR, β-arrestin, and G protein.

TL;DR: In this article, the authors show that Orai1 and STIM1 are also required for TRPC1-SOC channels, and that dynamic assembly of TRPC 1-STIM 1-Orai 1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion.

TL;DR: The data presented here reveal that all three proteins are essential for generation of ISOC in these cells and that dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion, suggesting a common molecular basis for SOC and CRAC channels.

TL;DR: Stabilization of two distinct β2AR conformations using single domain camelid antibodies (nanobodies) are reported—a previously described positive allosteric nanobody (Nb80) and a newly identified negative allosterics nanobodies (nb60) and demonstrate that ligands can initiate a wide range of cellular responses by differentially stabilizing multiple receptor states.

TL;DR: PM lipid rafts and caveolae are discussed as Ca(2+)-signaling microdomains and their importance in organizing and regulating SOCE channels is highlighted.