L
Li-Yin Huang
Researcher at Duke University
Publications - 21
Citations - 2293
Li-Yin Huang is an academic researcher from Duke University. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 15, co-authored 20 publications receiving 1855 citations. Previous affiliations of Li-Yin Huang include University of Tennessee & National Cheng Kung University.
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Journal ArticleDOI
Visualization of arrestin recruitment by a G-protein-coupled receptor
Arun K. Shukla,Gerwin Westfield,Kunhong Xiao,Rosana I. Reis,Li-Yin Huang,Prachi Tripathi-Shukla,Jiang Qian,Sheng Li,Adi Blanc,Austin N. Oleskie,Anne M. Dosey,Min Su,Cui Rong Liang,Ling Ling Gu,Jin Ming Shan,Xin Chen,Rachel Hanna,Minjung Choi,Xiao Jie Yao,Bjoern U. Klink,Alem W. Kahsai,Sachdev S. Sidhu,Shohei Koide,Pawel A. Penczek,Anthony A. Kossiakoff,Virgil L. Woods,Brian K. Kobilka,Georgios Skiniotis,Robert J. Lefkowitz +28 more
TL;DR: A strategy for forming and purifying a functional human β2AR–β-arrestin-1 complex is devised that provides a framework for better understanding the basis of GPCR regulation by arrestins.
Journal ArticleDOI
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Alex R.B. Thomsen,Bianca Plouffe,Thomas J. Cahill,Arun K. Shukla,Jeffrey T. Tarrasch,Annie M. Dosey,Alem W. Kahsai,Ryan T. Strachan,Biswaranjan Pani,Jacob P. Mahoney,Li-Yin Huang,Billy Breton,Franziska M. Heydenreich,Roger K. Sunahara,Roger K. Sunahara,Georgios Skiniotis,Michel Bouvier,Robert J. Lefkowitz,Robert J. Lefkowitz +18 more
TL;DR: This work has used a variety of biochemical, biophysical, and cell-based methods to demonstrate the existence, functionality, and architecture of internalized receptor complexes composed of a single GPCR, β-arrestin, and G protein.
Journal ArticleDOI
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
Arun K. Shukla,Aashish Manglik,Andrew C. Kruse,Kunhong Xiao,Rosana I. Reis,Wei Chou Tseng,Dean P. Staus,Daniel Hilger,Serdar Uysal,Li-Yin Huang,Marcin Paduch,Prachi Tripathi-Shukla,Akiko Koide,Shohei Koide,William I. Weis,Anthony A. Kossiakoff,Brian K. Kobilka,Robert J. Lefkowitz,Robert J. Lefkowitz +18 more
TL;DR: The crystal structure of β-arrestin-1 in complex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the human V2 vasopressin receptor is reported, and results indicate a potentially general molecular mechanism for activation of these multifunctional signalling and regulatory proteins.
Journal ArticleDOI
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
Thomas J. Cahill,Alex R.B. Thomsen,Jeffrey T. Tarrasch,Bianca Plouffe,Anthony H. Nguyen,Fan Yang,Li-Yin Huang,Alem W. Kahsai,Daniel L. Bassoni,Bryant J. Gavino,Jane Lamerdin,Sarah Triest,Sarah Triest,Arun K. Shukla,Arun K. Shukla,Benjamin Berger,John Little,Albert Antar,Adi Blanc,Chang Xiu Qu,Xin Chen,Kouki Kawakami,Asuka Inoue,Asuka Inoue,Junken Aoki,Junken Aoki,Jan Steyaert,Jan Steyaert,Jin-Peng Sun,Michel Bouvier,Georgios Skiniotis,Robert J. Lefkowitz +31 more
TL;DR: A mutant form of βarr lacking the “finger-loop” region is created, which is found that the tail conformation preserves the ability to mediate receptor internalization and βarr signaling but not desensitization of G protein signaling.
Journal ArticleDOI
Identification of Medically Important Molds by an Oligonucleotide Array
Chen Ren Hsiao,Li-Yin Huang,Jean-Philippe Bouchara,Richard Barton,Hsin Chieh Li,Tsung Chain Chang +5 more
TL;DR: The present array is a powerful tool for identification of clinically important filamentous fungi and may have the potential to be continually extended by adding further oligonucleotides to the array without significantly increasing the cost or complexity.