R
Ritu Khurana
Researcher at University of California, Santa Cruz
Publications - 15
Citations - 3880
Ritu Khurana is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Fibril & Amyloid. The author has an hindex of 15, co-authored 15 publications receiving 3608 citations.
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Journal ArticleDOI
Effect of Environmental Factors on the Kinetics of Insulin Fibril Formation: Elucidation of the Molecular Mechanism
Liza Nielsen,Ritu Khurana,Alisa C. Coats,Sven Frokjaer,Jens Brange,Sandip Vyas,Vladimir N. Uversky,Anthony L. Fink +7 more
TL;DR: The results indicated that both nucleation and fibril growth were controlled by hydrophobic and electrostatic interactions.
Journal ArticleDOI
Mechanism of thioflavin T binding to amyloid fibrils
Ritu Khurana,Chris Coleman,Cristian Ionescu-Zanetti,Sue A. Carter,Vinay Krishna,Rajesh K. Grover,Raja Roy,Shashi Singh +7 more
TL;DR: The data suggests that the micelles of thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission, which suggests that positive charge on the thioFlavin T molecule has a role in its micelle formation that then bind the amyloids fibril.
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Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates.
Ritu Khurana,Joel R. Gillespie,Anupam Talapatra,Lauren J. Minert,Cristian Ionescu-Zanetti,Ian S. Millett,Anthony L. Fink +6 more
TL;DR: The data support the hypothesis that amyloid fibril formation involves the ordered self-assembly of partially folded species that are critical soluble precursors of fibrils.
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Is Congo Red an Amyloid-specific Dye?
TL;DR: The data suggest that Congo red is sandwiched between two protein molecules causing protein oligomerization, which shows that it must be used with caution as a diagnostic test for the presence of amyloid fibrils in vitro.
Journal ArticleDOI
A General Model for Amyloid Fibril Assembly Based on Morphological Studies Using Atomic Force Microscopy
Ritu Khurana,Cristian Ionescu-Zanetti,Maighdlin Pope,Jie Li,Liza Nielson,Marina Ramirez-Alvarado,Lynn Regan,Anthony L. Fink,Sue A. Carter +8 more
TL;DR: It is proposed that the hierarchical assembly model describes a general mechanism of assembly for all amyloid fibrils.