Robert A. Zinna

TL;DR: Rat macrophages transduced with recombinant adenovirus and bone marrow cells of MKP-1 KO mice significantly decreased IL-6, IL-10, TNF-α and chemokine levels, and formed fewer osteoclasts induced by LPS than compared with control group of cells, indicating that MKp-1 is a key therapeutic target to control of inflammation-induced bone loss.

TL;DR: Deep parallels in the development of rhinoceros and dung beetle horns are highlighted, suggesting either that both horn types arose in the common ancestor of all scarabs, a surprising reconstruction of horn evolution that would mean the majority of scarab species actively repress horn growth, or that parallel origins of these extravagant structures resulted from repeated co-option of the same underlying developmental processes.

TL;DR: RNAseq analysis is used to build on recent work exploring mechanisms in the exaggerated weapons of beetles, by examining patterns of differential gene expression in exaggerated and non‐exaggerated traits in the Asian rhinoceros beetle, Trypoxylus dichotomus, to suggest that sexually dimorphic expression of weaponry involves large‐scale changes in gene expression, relative to other traits, while nutrition‐driven changes inGene expression in these same weapons are less pronounced.

TL;DR: This proof-of-concept study suggests a novel target using an intraoral RNA interference strategy to control periodontal inflammation, and validated MK2 siRNA specificity and arrested LPS-induced inflammatory bone loss, decreased inflammatory infiltrate, and decreased osteoclastogenesis.

TL;DR: The results indicate that the roles of CmSxl and Cmtra2 in the sex determination cascade are likely to have diverged in stag beetles when compared to Drosophila, and suggest that Cmix has a conserved role in this pathway.