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Keith L. Kirkwood
Researcher at Roswell Park Cancer Institute
Publications - 114
Citations - 7191
Keith L. Kirkwood is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Periodontitis & Inflammation. The author has an hindex of 39, co-authored 107 publications receiving 5688 citations. Previous affiliations of Keith L. Kirkwood include University at Buffalo & State University of New York System.
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Journal ArticleDOI
Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Panos N. Papapanou,Mariano Sanz,Nurcan Buduneli,Thomas Dietrich,Magda Feres,Daniel H. Fine,Thomas Frank Flemmig,Raul I. Garcia,William V. Giannobile,Filippo Graziani,Henry Greenwell,David Herrera,Richard T. Kao,Moritz Kebschull,Moritz Kebschull,Denis F. Kinane,Keith L. Kirkwood,Thomas Kocher,Kenneth S. Kornman,Purnima S. Kumar,Bruno G. Loos,Eli E. Machtei,Huanxin Meng,Andrea Mombelli,Ian Needleman,Steven Offenbacher,Gregory J. Seymour,Ricardo Teles,Maurizio S. Tonetti +28 more
TL;DR: A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system as mentioned in this paper.
Journal ArticleDOI
Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement
George Hajishengallis,Shuang Liang,Mark A. Payne,Ahmed Hashim,Ravi Jotwani,Mehmet A. Eskan,Megan L. McIntosh,Asil Alsam,Keith L. Kirkwood,John D. Lambris,Richard P. Darveau,Michael A. Curtis +11 more
TL;DR: It is shown that P. gingivalis, at very low colonization levels, triggers changes to the amount and composition of the oral commensal microbiota leading to inflammatory periodontal bone loss, demonstrating that a single, low-abundance species can disrupt host-microbial homeostasis to cause inflammatory disease.
Journal ArticleDOI
Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions: Classification and case definitions for periodontitis
Panos N. Papapanou,Mariano Sanz,Nurcan Buduneli,Thomas Dietrich,Magda Feres,Daniel H. Fine,Thomas Frank Flemmig,Raul I. Garcia,William V. Giannobile,Filippo Graziani,Henry Greenwell,David Herrera,Richard T. Kao,Moritz Kebschull,Moritz Kebschull,Denis F. Kinane,Keith L. Kirkwood,Thomas Kocher,Kenneth S. Kornman,Purnima S. Kumar,Bruno G. Loos,Eli E. Machtei,Huanxin Meng,Andrea Mombelli,Ian Needleman,Steven Offenbacher,Gregory J. Seymour,Ricardo Teles,Maurizio S. Tonetti +28 more
TL;DR: A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system.
Journal ArticleDOI
Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members
Matthew J. Ruddy,Grace C. Wong,Xikui Liu,Hiroyasu Yamamoto,Soji Kasayama,Keith L. Kirkwood,Sarah L. Gaffen +6 more
TL;DR: It is shown that at least part of the functional cooperation between IL-17 and TNFα occurs at the level of IL-6 gene transcription, and that C/EBPδ (or the related transcription factor C-EBPβ) is essential for expression ofIL-6.
Journal ArticleDOI
Novel host response therapeutic approaches to treat periodontal diseases.
TL;DR: This review has sought to provide mechanistic overviews and clinical applications on the use of host modulatory therapeutic regimens for periodontal disease management by using gene therapy vectors to provide a longer-term delivery of tumor necrosis factor receptor antagonists at the periodontium.