R
Robert B. Hinton
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 93
Citations - 4069
Robert B. Hinton is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Aortic valve & Bicuspid aortic valve. The author has an hindex of 29, co-authored 93 publications receiving 3604 citations. Previous affiliations of Robert B. Hinton include University of Cincinnati Academic Health Center & Nationwide Children's Hospital.
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Journal ArticleDOI
Heart Valve Structure and Function in Development and Disease
TL;DR: The mature heart valves are made up of highly organized extracellular matrix (ECM) and valve interstitial cells (VICs) surrounded by an endothelial cell layer that confer distinct biomechanical properties to the leaflets and supporting structures.
Journal ArticleDOI
Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves
Robert B. Hinton,Joy Lincoln,Gail H. Deutsch,Hanna Osinska,Peter B. Manning,D. Woodrow Benson,Katherine E. Yutzey +6 more
TL;DR: These studies show that normal valve development is characterized by spatiotemporal coordination of ECM organization and VIC compartmentalization and that these developmental processes are disrupted in pediatric patients with diseased BAVs.
Journal ArticleDOI
Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart
Paige Snider,Robert B. Hinton,Ricardo A. Moreno-Rodriguez,Jian Wang,Rhonda Rogers,Andrew Lindsley,Fang Li,David A. Ingram,Donald R. Menick,Loren J. Field,Anthony B. Firulli,Jeffery D. Molkentin,Roger R. Markwald,Simon J. Conway +13 more
TL;DR: Assessment of collagen production, 3D lattice formation ability, and transforming growth factor-&bgr; responsiveness indicate periostin-deficient fibroblasts are unable to support normal valvular remodeling and establishment of a mature cardiac skeleton.
Journal ArticleDOI
Hypoplastic Left Heart Syndrome Is Heritable
Robert B. Hinton,Lisa J. Martin,Meredith E. Tabangin,Mjaye L. Mazwi,Linda H. Cripe,D. Woodrow Benson +5 more
TL;DR: The frequent occurrence of left- and right-sided valve dysplasia in HLHS probands and the increased prevalence of BAV in family members suggests that HLHS is a severe form of valve malformation.
Journal ArticleDOI
Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations
Lisa J. Martin,Vijaya Ramachandran,Linda H. Cripe,Robert B. Hinton,Gregor Andelfinger,Gregor Andelfinger,Meredith E. Tabangin,Kerry A. Shooner,Mehdi Keddache,D. Woodrow Benson +9 more
TL;DR: In this genome-wide scan, it is demonstrated for the first time, that BAV and/or associated CVM exhibit linkage to chromosomes 18q, 5q and 13q, indicating their important role in valvulogenesis and cardiac development.