P
Paola Sacerdote
Researcher at University of Milan
Publications - 241
Citations - 11324
Paola Sacerdote is an academic researcher from University of Milan. The author has contributed to research in topics: Immune system & Peripheral blood mononuclear cell. The author has an hindex of 55, co-authored 237 publications receiving 10404 citations.
Papers
More filters
Journal ArticleDOI
Opioids and the management of chronic severe pain in the elderly: Consensus statement of an international expert panel with focus on the six clinically most often used world health organization step III opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)
Joseph V. Pergolizzi,Rainer H. Böger,Keith Budd,Albert Dahan,Serdar Erdine,Guy Hans,Hans G. Kress,Richard M. Langford,Rudolf Likar,Robert B. Raffa,Paola Sacerdote +10 more
TL;DR: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy, overall side‐effect profile, onset of action, drug interactions, abuse potential, and practical issues, such as cost and availability of the drug, as well as the severity and type of pain.
Journal ArticleDOI
Effects of ACL Reconstructive Surgery on Temporal Variations of Cytokine Levels in Synovial Fluid.
Marco Bigoni,Marco Turati,Marta Gandolla,Paola Sacerdote,Massimiliano Piatti,Alberto Castelnuovo,Silvia Franchi,Massimo Gorla,Daniele Munegato,Diego Gaddi,Alessandra Pedrocchi,Robert J. Omeljaniuk,Vittorio Locatelli,Antonio Torsello +13 more
TL;DR: The data show that the history of an ACL injury, including trauma and reconstruction, has a significant impact on levels of IL-6, IL-8, and IL-10 in synovial fluid but does not affect levels of TNF-α andIL-1β.
Journal ArticleDOI
The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.
Paola Sacerdote,Mauro Bianchi,Leda Gaspani,Barbara Manfredi,Antonio Maucione,Giovanni Terno,Mario Ammatuna,Alberto E. Panerai +7 more
TL;DR: Tramadol, in contrast to morphine, induced an improvement of postoperative immunosuppression and, therefore, may be preferred to morphine for the treatment of post operative pain.
Journal ArticleDOI
Current knowledge of buprenorphine and its unique pharmacological profile.
Joseph V. Pergolizzi,Anna Maria Aloisi,Albert Dahan,Joerg Filitz,Richard M. Langford,Rudolf Likar,Sebastiano Mercadante,Bart Morlion,Robert B. Raffa,Rainer Sabatowski,Paola Sacerdote,Luis Torres,Avi A. Weinbroum +12 more
TL;DR: Buprenorphine exhibits a pronounced antihyperalgesic effect that might indicate potential advantages in the treatment of neuropathic pain, and its favorable safety profile and proven efficacy in severe pain and favorable tolerability mean that it can be considered a safe and effective option for treating chronic cancer and noncancer pain.
Journal ArticleDOI
Opioids and the immune system.
TL;DR: Overall, from several animal studies it emerges that buprenorphine has the more favourable profile, being a potent analgesic devoid of intrinsic immunosuppressive activity.