Robert Dunstan

TL;DR: In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner, accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores.

TL;DR: For IHC to be considered a “top-tier” biomarker assay, it must provide truly quantitative data on par with non-morphologic assays, which means it needs to be run with reference standards, but creating such standards for IHC will require optimizing all aspects of tissue collection, fixation, section thickness, morphologic criteria for assessment, staining processes, digitization of images, and image analysis.

TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.

TL;DR: Data is presented demonstrating that a novel, selective and potent small molecule RORγ inhibitor can block the ROR γ‐dependent gene expression programme in both Th17 cells and R ORγ‐expressing γδ T cells as well as a disease‐relevant subset of human Rorγ‐ expressing memory T cells.

TL;DR: In this article, the effect of IL-22 on barrier function was assessed in polarized T-84 cell monolayers and showed that it led to epithelial stem cell expansion, proliferation, barrier dysfunction and anti-microbial peptide production.