Christoph Hock

TL;DR: In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner, accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores.

TL;DR: New insights into constitutional metabolic changes in neurons from subjects prone to develop Alzheimer's pathology are given and suggest that increased ROS production may have an integral role in the development of sporadic AD prior to the appearance of amyloid and tau pathology.

TL;DR: A role for the prion protein in the formation of long-term memory in humans is suggested after carriers of either the 129MM or the 129MV genotype recalled 17% more information than 129VV carriers, but short- term memory was unaffected.

TL;DR: The results imply that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species, and 6C5 most efficiently blocked uptake and subsequent aggregation and blocked neuron-to-neuron spreading of tau in a unique three-chamber microfluidic device.

TL;DR: BALM imaging is employed to acquire superresolution images of α-synuclein amyloid fibrils with unprecedented optical resolution and it is proposed that BALM imaging can be extended to study the structure of other amyloids, for differential diagnosis of amyloidal-related diseases and for discovery of drugs that perturbAmyloid structure for therapy.