F
Fang Qian
Researcher at Biogen Idec
Publications - 22
Citations - 3844
Fang Qian is an academic researcher from Biogen Idec. The author has contributed to research in topics: B-cell activating factor & BAFF receptor. The author has an hindex of 15, co-authored 21 publications receiving 3558 citations.
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Journal ArticleDOI
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Jeffrey Thompson,Sarah A. Bixler,Fang Qian,Kalpit Vora,Martin L. Scott,Teresa G. Cachero,Catherine Hession,Pascal Schneider,Irene Sizing,Colleen Mullen,Kathy Strauch,Mohammad Zafari,Christopher D. Benjamin,Jürg Tschopp,Jeffrey L. Browning,Christine Ambrose +15 more
TL;DR: BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice.
Journal ArticleDOI
BAFF mediates survival of peripheral immature B lymphocytes.
Marcel Batten,Joanna R Groom,Teresa G. Cachero,Fang Qian,Pascal Schneider,Jürg Tschopp,Jeffrey L. Browning,Fabienne Mackay +7 more
TL;DR: A model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment is supported, providing new clues on mechanisms regulating B cell maturation and tolerance.
Journal ArticleDOI
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells
Lai Guan Ng,Andrew P. R. Sutherland,Rebecca Newton,Fang Qian,Teresa G. Cachero,Martin L. Scott,Jeffrey Thompson,Julie Wheway,Tatyana Chtanova,Joanna R Groom,Ian Sutton,Cynthia Xin,Stuart G. Tangye,Susan L. Kalled,Fabienne Mackay,Charles R. Mackay +15 more
TL;DR: BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells.
Journal ArticleDOI
Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population
Jeffrey Thompson,Pascal Schneider,Susan L. Kalled,Li Chun Wang,Eric A. Lefevre,Teresa G. Cachero,Fabienne Mackay,Sarah A. Bixler,Mohammad Zafari,Zhong-Ying Liu,Stephen A. Woodcock,Fang Qian,Marcel Batten,Christine Madry,Yolande Richard,Christopher D. Benjamin,Jeffrey L. Browning,Andreas Tsapis,Jürg Tschopp,Christine Ambrose +19 more
TL;DR: A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo, consistent with a role for BAFF in maintaining homeostasis of the B cell population.
Journal ArticleDOI
A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth
Paul Rennert,Pascal Schneider,Teresa G. Cachero,Jeffrey Thompson,Luciana Trabach,Sylvie Hertig,Nils Holler,Fang Qian,Colleen Mullen,Kathy Strauch,Jeffrey L. Browning,Christine Ambrose,Jürg Tschopp +12 more
TL;DR: An important role is suggested for APRIL in tumorigenesis and a novel anticancer strategy is pointed towards by identifying B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family.