R
Robert G. Ulrich
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 52
Citations - 1493
Robert G. Ulrich is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Antigen & Vaccination. The author has an hindex of 24, co-authored 52 publications receiving 1403 citations. Previous affiliations of Robert G. Ulrich include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Development of engineered vaccines effective against structurally related bacterial superantigens
TL;DR: It is concluded that an optimal combination of these genetically attenuated superantigen vaccines may protect against all structurally related superantigens.
Journal ArticleDOI
Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A.
TL;DR: These results, combined with an understanding of the molecular nature of superantigen and receptor interactions, indicate that targeting MHC class II binding by site-directed mutagenesis will produce the most effective vaccine.
Journal ArticleDOI
Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity
James W. Boles,M. Louise M. Pitt,Ross D. LeClaire,Paul H. Gibbs,Edna R. Torres,Beverly Dyas,Robert G. Ulrich,Sina Bavari +7 more
TL;DR: It is suggested that the attenuated SEB is fully protective against aerosolized toxin when administered to unprimed subjects and various biomarkers that showed substantial promise as correlates of immunity and surrogate endpoints for assessing in vivo biological responses in primates, and possibly in humans, to vaccines against SEs.
Journal ArticleDOI
Mucosal Vaccination with Recombinantly Attenuated Staphylococcal Enterotoxin B and Protection in a Murine Model
TL;DR: Mice vaccinated mucosally were protected against a 50% lethal dose of wild-type SEB given i.p. or mucosal, thus demonstrating that nasal or oral administration of this SEBv elicits systemic and mucosal antibodies to SEB that protect against SEB-induced lethal shock.
Journal ArticleDOI
Staphylococcal enterotoxins A and B share a common structural motif for binding class II major histocompatibility complex molecules.
TL;DR: An examination of the experimental data with the homology model clarifies how T-cell responses to enterotoxin A, and most bacterial superantigens, are likely to be mediated by variations of a structurally conserved HLA-DRα binding motif.