Robert H. Shoemaker

TL;DR: Data filtering, based on restricted cellular cytotoxicity profiles from chemically similar sets of compounds, has been used to select a class of benzothiazoles for subsequent microarray gene expression measurements in the most chemosensitive tumor cell line, and the results confirmed observations that P450 metabolizing isoforms are overexpressed in MCF-7 tumor cells following treatment with Benzothiazole.

TL;DR: A rapid mechanistic plate assay is provided and its potential application to high-throughput screening of libraries of Libraries of tens of thousands of chemical compounds to identify inhibitors of processive DNA synthesis is provided.

TL;DR: 4A6 is a novel specific inhibitor of the β5 subunit-associated chymotrypsin-like proteasome activity of the 26S proteasomes.

TL;DR: It is concluded that this model of squamous cell bronchogenic carcinoma should prove useful in the study of tumor ultrastructure, the immunologic response to cancer, and the relationship of diet to cancer.

TL;DR: Several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening are developed, which may provide practical models for experimental drug and immunotherapeutic trials.