R
Robert J. Lederman
Researcher at National Institutes of Health
Publications - 283
Citations - 9529
Robert J. Lederman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Interventional magnetic resonance imaging & Mitral valve replacement. The author has an hindex of 48, co-authored 256 publications receiving 8170 citations. Previous affiliations of Robert J. Lederman include Durham University & Duke University.
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Regional Angiogenesis With Vascular Endothelial Growth Factor in Peripheral Arterial Disease A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Claudication
Sanjay Rajagopalan,Emile R. Mohler,Robert J. Lederman,Farrell O. Mendelsohn,Jorge F. Saucedo,Corey K. Goldman,John Blebea,Jennifer Macko,Paul D. Kessler,Henrik S. Rasmussen,Brian H. Annex +10 more
TL;DR: A single unilateral intramuscular administration of AdVEGF121 was not associated with improved exercise performance or quality of life in this study, and this study does not support local delivery of single-dose VEGF121 as a treatment strategy in patients with unilateral PAD.
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Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial
Robert J. Lederman,Farrell O. Mendelsohn,R. David Anderson,Jorge F Saucedo,Alan N. Tenaglia,James B. Hermiller,William B. Hillegass,Krishna J. Rocha-Singh,Thomas Moon,M.J. Whitehouse,Brian H. Annex +10 more
TL;DR: Intra-arterial rFGF-2 resulted in a significant increase in peak walking time at 90 days; repeat infusion at 30 days was no better than one infusion and the findings of TRAFFIC provide evidence of clinical therapeutic angiogenesis by intra-arteria infusion of an angiogenic protein.
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Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells
Jonathan Hill,Alexander Dick,Venkatesh K. Raman,Richard B. Thompson,Zu Xi Yu,K. Allison Hinds,Breno S.S. Pessanha,Michael A. Guttman,Timothy R. Varney,Bradley J. Martin,Cynthia E. Dunbar,Elliot R. McVeigh,Robert J. Lederman +12 more
TL;DR: IFP labeling of MSCs imparts useful MRI contrast, enabling ready detection in the beating heart on a conventional cardiac MR scanner after transplantation into normal and infarcted myocardium.
Journal ArticleDOI
NT5E mutations and arterial calcifications.
Cynthia St. Hilaire,Shira G. Ziegler,Thomas C. Markello,Alfredo Brusco,Catherine Groden,Fred Gill,Hannah Carlson-Donohoe,Robert J. Lederman,Marcus Y. Chen,Dan Yang,Michael P. Siegenthaler,Carlo Arduino,Cecilia Mancini,Bernard Freudenthal,Horia Stanescu,Anselm A. Zdebik,R. Krishna Chaganti,Robert L. Nussbaum,Robert Kleta,William A. Gahl,Manfred Boehm +20 more
TL;DR: Clinical, radiographic, and genetic studies in three families with symptomatic arterial calcifications identified nine persons with calcifications of the lower-extremity arteries and hand and foot joint capsules, all five siblings in one family, three siblings in another, and one patient in a third family.
Journal ArticleDOI
Magnetic Resonance Fluoroscopy Allows Targeted Delivery of Mesenchymal Stem Cells to Infarct Borders in Swine
Alexander Dick,Michael A. Guttman,Venkatesh K. Raman,Dana C. Peters,Breno S.S. Pessanha,Jonathan Hill,Scott R. Smith,Greig C. Scott,Elliot R. McVeigh,Robert J. Lederman +9 more
TL;DR: Precise targeted delivery of potentially regenerative cellular treatments to recent myocardial infarction borders is feasible with an MR catheter delivery system.