Catherine Groden

TL;DR: Treatment with a monoclonal antibody against interleukin-12 may induce clinical responses and remissions in patients with active Crohn's disease and is associated with decreases in Th1-mediated inflammatory cytokines at the site of disease.

TL;DR: Clinical, radiographic, and genetic studies in three families with symptomatic arterial calcifications identified nine persons with calcifications of the lower-extremity arteries and hand and foot joint capsules, all five siblings in one family, three siblings in another, and one patient in a third family.

TL;DR: It is concluded that CD but not ulcerative colitis is associated with high levels of both IL‐12p70 and IL‐23 secretion as well as the secretion of downstream effector cytokines, and that this cytokine production is down‐regulated following administration of IL‐ 12p40 mAb.

TL;DR: The National Institutes of Health Undiagnosed Diseases Program addresses an unmet need and may serve as a model for the clinical application of emerging genomic technologies and is providing insights into the characteristics of diseases that remain undiagnose after extensive clinical workup.

TL;DR: MARRVEL dramatically improves efficiency and accessibility to data collection and facilitates analysis of human genes and variants by cross-disciplinary integration of 18 million records available in public databases to facilitate clinical diagnosis and basic research.