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Robert J. North
Researcher at Trudeau Institute
Publications - 125
Citations - 13728
Robert J. North is an academic researcher from Trudeau Institute. The author has contributed to research in topics: Mycobacterium tuberculosis & Immunity. The author has an hindex of 59, co-authored 125 publications receiving 13450 citations.
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Journal ArticleDOI
Identification of nitric oxide synthase as a protective locus against tuberculosis
TL;DR: NOS2(-/-) mice proved highly susceptible, resembling wild-type littermates immunosuppressed by high-dose glucocorticoids, and allowed Mycobacterium tuberculosis to replicate faster in the lungs than reported for other gene-deficient hosts.
Journal ArticleDOI
Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice
Bao Lu,Barbara J. Rutledge,Long Gu,Joseph Fiorillo,Nicholas W. Lukacs,Steven L. Kunkel,Robert J. North,Craig Gerard,Barrett J. Rollins +8 more
TL;DR: It is indicated that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses.
Journal ArticleDOI
Immunity to tuberculosis.
Robert J. North,Yu-Jin Jung +1 more
TL;DR: In this article, it was shown that only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and over 85% of them develop the disease exclusively in the lungs.
Book ChapterDOI
Down-Regulation of the Antitumor Immune Response
TL;DR: It is suggested that down-regulation of antitumor immunity by suppressor T cells can explain the escape of only of those tumors that are immunogenic enough to evoke the generation of enough effectors T cells to cause tumor regression in the absence of suppressing T cells.
Journal ArticleDOI
The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice.
TL;DR: Wild-type and targeted-mutant mice incapable of making αβ T cells, γδ T cells), class I major histocompatibility complex (MHC), class II MHC, interferon (IFN)-γ, or inducible nitric oxide synthase (NOS2) were infected with Mycobacterium tuberculosis by aerosol and monitored over time for their ability to control infection, develop histopathology at sites of infection, and survive.