Molecular biology of microbial ureases.

Microbial ureases: significance, regulation, and molecular characterization.

Catalytic promiscuity and the evolution of new enzymatic activities

Ureases (urea amidohydrolases, EC 3.5.1.5) are a group of highly proficient enzymes, widely distributed in nature, whose catalytic function is to catalyze the hydrolysis of urea, its final products being carbonic acid and ammonia. The products and the resulting increase in pH of the reaction environment are consequential characteristics of the action of ureases. Apart from its natural significance, ureases-catalyzed hydrolysis of urea is important in that it has great potential for practical applications. In view of this importance, this article offers a review of the properties of the enzymes, where in addition to the established knowledge, the recent findings are presented. Special emphasis is put on the functional and practical properties of ureases that can be customized and exploited in a diversity of important applications, notably medical, analytical, environmental and engineering.

Ureases I. Functional, catalytic and kinetic properties: A review

http://users.man.poznan.pl/wojtekr/pdf/wr-lit-20.pdf

A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels.

Nickel(II)-promoted ethanolysis and hydrolysis of N-(2-pyridylmethyl)urea. A model for urease

Etude comparee de la degradation enzymatique et non enzymatique de l'uree Proprietes physicochimiques de l'urease et son mecanisme de reaction

Urea and urease.

Jack bean urease (EC 3.5.1.5). VIII: On the inhibition of urease by amides and esters of phosphoric acid

Jack Bean Urease VI. Determination of thiol and disulfide content: Reversible inactivation of the enzyme by the blocking of the unique cysteine residue☆

Robert K. Andrews

Papers

Nickel(II)-promoted ethanolysis and hydrolysis of N-(2-pyridylmethyl)urea. A model for urease

Urea and urease.

Jack bean urease (EC 3.5.1.5). VIII: On the inhibition of urease by amides and esters of phosphoric acid

Jack Bean Urease VI. Determination of thiol and disulfide content: Reversible inactivation of the enzyme by the blocking of the unique cysteine residue☆

Jack Bean Urease (EC 3.5.1.5). Part 8. Inhibition of Urease by Amides and Esters of Phosphoric Acid.