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Robert L. Martuza
Researcher at Harvard University
Publications - 264
Citations - 30135
Robert L. Martuza is an academic researcher from Harvard University. The author has contributed to research in topics: Oncolytic virus & Herpes simplex virus. The author has an hindex of 79, co-authored 263 publications receiving 27228 citations. Previous affiliations of Robert L. Martuza include Georgetown University Medical Center & House Ear Institute.
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Journal ArticleDOI
Angiogenic Response Caused by Oncolytic Herpes Simplex Virus–Induced Reduced Thrombospondin Expression Can Be Prevented by Specific Viral Mutations or by Administering a Thrombospondin-Derived Peptide
TL;DR: Oncolytic HSV G207 retains the ability of WT HSV to increase infected tissue vascularity in infected tumors, and incorporating viral mutations, such as those seen in G47Delta or administering thrombospondin-derived peptides, counteracts the angiogenic effect of oncolytics HSV and should be considered when designing oncolynic HSV therapies.
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Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo
Shin-ichi Miyatake,Tani S,F Feigenbaum,Periasamy Sundaresan,Hiroki Toda,Narumi O,Haruhiko Kikuchi,Nobuo Hashimoto,Hangai M,Robert L. Martuza,Samuel D. Rabkin +10 more
TL;DR: Recombinant HSV G92A regulated by the albumin enhancer/promoter inhibited the growth of established subcutaneous hepatoma tumors in nude mice, but not prostate tumors, suggestingReplication-competent viral vectors controlled by cell-specific transcriptional regulatory sequences provide a new therapeutic strategy for tumor therapy.
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Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancer.
Timothy J. Jorgensen,Sanford Katz,Ellen K. Wittmack,Susan Varghese,Tomoki Todo,Samuel D. Rabkin,Robert L. Martuza +6 more
TL;DR: G207, a multimutated HSV type 1 vector, with external beam radiation therapy of prostate tumors grown subcutaneously in mice found that individually, either G207 or radiation was effective in delaying tumor growth in these models.
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Oncolytic Herpes Simplex Virus Vector G47Δ in Combination with Androgen Ablation for the Treatment of Human Prostate Adenocarcinoma
TL;DR: Oncolytic virus therapy with G47Δ can be usefully combined with androgen ablation therapy for the treatment of prostate cancer, and the combination therapy led to significantly enhanced inhibition of the tumor growth and prolonged survival.
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Symptomatic spinal epidural lipomatosis associated with Cushing's syndrome
TL;DR: Although it is an unusual complication of Cushing's syndrome, epidural lipomatosis should be considered in the differential diagnosis of any such case with neurological symptoms referable to the spinal cord or cauda equina.