R
Robert L. Martuza
Researcher at Harvard University
Publications - 264
Citations - 30135
Robert L. Martuza is an academic researcher from Harvard University. The author has contributed to research in topics: Oncolytic virus & Herpes simplex virus. The author has an hindex of 79, co-authored 263 publications receiving 27228 citations. Previous affiliations of Robert L. Martuza include Georgetown University Medical Center & House Ear Institute.
Papers
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Journal ArticleDOI
Intracarotid delivery of oncolytic HSV vector G47Δ to metastatic breast cancer in the brain
TL;DR: This is the first demonstration of intracarotid arterial delivery of oncolytic HSV vectors and antitumor efficacy in a mouse model and opens the door to the use of mouse syngenic tumor models and transgenic/knockout animals.
Journal ArticleDOI
Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models.
Wei Zhang,Wei Zhang,Giulia Fulci,Hiroaki Wakimoto,Tooba A. Cheema,Jason S. Buhrman,Deva S. Jeyaretna,Anat O. Stemmer Rachamimov,Samuel D. Rabkin,Robert L. Martuza +9 more
TL;DR: Data support the paradigm of using oHSV expressing different antiangiogenic agents and show for the first time that oHSVs expressing angiostatin and IL-12 can improve efficacy in human GBM models.
Patent
Tumor- or cell-specific herpes simplex virus replication
TL;DR: In this article, a method for killing tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells, which are driven by a tumor-specific or cell-specific promoter that specifically destroys tumor cells and is not neurovirulent.
Journal ArticleDOI
Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma
Wei Zhang,Giulia Fulci,Jason S. Buhrman,Anat Stemmer-Rachamimov,John W. Chen,Gregory R. Wojtkiewicz,Ralph Weissleder,Samuel D. Rabkin,Robert L. Martuza +8 more
TL;DR: Results indicate that injection of G47Δ-mAngio during BEV treatment allows increased virus spread, tumor lysis, and angiostatin-mediated inhibition of vascular endothelial growth factor expression and of BEV-induced invasion markers, which leads to increased survival and antiangiogenesis and decreased invasive phenotypes.
Journal ArticleDOI
Distribution, retention, and phototoxicity of hematoporphyrin derivative in a rat glioma. Intraneoplastic versus intraperitoneal injection.
TL;DR: Both in vitro and in vivo clonogenic assays demonstrated that the photodynamic inactivation of the tumors was significantly greater after direct injection than after intraperitoneal injection.