R
Robert L. Martuza
Researcher at Harvard University
Publications - 264
Citations - 30135
Robert L. Martuza is an academic researcher from Harvard University. The author has contributed to research in topics: Oncolytic virus & Herpes simplex virus. The author has an hindex of 79, co-authored 263 publications receiving 27228 citations. Previous affiliations of Robert L. Martuza include Georgetown University Medical Center & House Ear Institute.
Papers
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Journal ArticleDOI
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470.
Takahito Yazaki,Yoshiaki Takamiya,Penelope C. Costello,Toshihiro Mineta,Anil G. Menon,Samuel D. Rabkin,Robert L. Martuza +6 more
TL;DR: Inhibition of tumor-induced angiogenesis by TNP-470 (previously termed AGM-1470), a synthetic analogue of fumagillin, was tested on the growth of human non-malignant and malignant meningiomas in nude mice and significantly inhibited tumor neovascularization and tumor growth.
Journal ArticleDOI
Circulating Growth Factor Levels Are Associated with Tumorigenesis in Neurofibromatosis Type 1
George A. Mashour,Pablo Hernáiz Driever,Melanie Hartmann,Stephanie N. Drissel,Tingguo Zhang,Bianca Scharf,Ursula Felderhoff-Müser,Sadatoshi Sakuma,Reinhard E Friedrich,Robert L. Martuza,Victor F. Mautner,Andreas Kurtz +11 more
TL;DR: Enhanced circulating growth factor levels contribute to diffuse tumorigenesis in NF1 and may provide the basis for molecular diagnosis, and stem cell factor and MK concentrations above a defined threshold in serum of NF1 patients are of diagnostic benefit.
Journal ArticleDOI
Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models.
TL;DR: In athymic mice bearing CWR22 prostate tumors, VB in combination with NV1042 was superior to the combination of VB plus NV1023 in reducing tumor burden, appeared to be nontoxic and resulted in a statistically significant diminution in the number of CD31+ cells as compared with other treatment groups.
Journal Article
Biological Purging of Breast Cancer Cells Using an Attenuated Replication-competent Herpes Simplex Virus in Human Hematopoietic Stem Cell Transplantation
Aiguo Wu,Amitabha Mazumder,Robert L. Martuza,Xia Liu,Myint Thein,Kenneth R. Meehan,Samuel D. Rabkin +6 more
TL;DR: The efficient infection of human bone marrow cells in the absence of detected toxicity suggests that HSV vectors may also prove useful for gene therapy to hematopoietic progenitor cells.
Patent
Use of oncolytic herpes viruses for killing cancer stem cells
TL;DR: In this article, an oncolytic Herpes virus mediated on-colysis was used for selective killing of cancer stem cells, which was shown to be effective in treating a cancer stem cell.