R
Robert L. Shone
Researcher at University of Illinois at Chicago
Publications - 4
Citations - 233
Robert L. Shone is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Calanolide A & Luche reduction. The author has an hindex of 3, co-authored 4 publications receiving 213 citations.
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Journal ArticleDOI
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy- 2-methylbutan-2-ol, cyclization, and Luche reduction.
Journal ArticleDOI
Novel approach for synthesis of (±)-calanolide a and its anti-HIV activity
Alla Kucherenko,Michael T. Flavin,William A. Boulanger,Albert Khilevich,Robert L. Shone,John D. Rizzo,Abram Kivovich Sheinkman,Ze-Qi Xu +7 more
TL;DR: The key intermediate, chromene 5, was synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan- 2-ol.
Journal ArticleDOI
Synthesis, Chromatographic Resolution, and Anti‐Human Immunodeficiency Virus Activity of (.+‐.)‐Calanolide A and Its Enantiomers.
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: In this article, the anti-HIV agent (±)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel−Crafts acylation, chromenylation with 4,4-dimethoxy-2-methylbutan-2ol, cyclization, and Luche reduction.
Journal ArticleDOI
Novel Approach for Synthesis of (.+‐.)‐Calanolide A and Its Anti‐HIV Activity.
Alla Kucherenko,Michael T. Flavin,William A. Boulanger,Albert Khilevich,Robert L. Shone,John D. Rizzo,Abram Kivovich Sheinkman,Ze-Qi Xu +7 more
TL;DR: In this paper, an anti-HIV agent (±)-calanolide A (1 ) has been synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan-2.2-ol.