W
Wei Chen
Researcher at Illinois Institute of Technology
Publications - 16
Citations - 312
Wei Chen is an academic researcher from Illinois Institute of Technology. The author has contributed to research in topics: Phosphonate & Luche reduction. The author has an hindex of 7, co-authored 16 publications receiving 290 citations. Previous affiliations of Wei Chen include University of Illinois at Chicago.
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Journal ArticleDOI
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy- 2-methylbutan-2-ol, cyclization, and Luche reduction.
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Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products
Albert Khilevich,Aye Aye Mar,Michael T. Flavin,John D. Rizzo,Lin Lin,S. Dzekhtser,D. Brankovic,Heping Zhang,Wei Chen,Shuyuan Liao,David E. Zembower,Ze-Qi Xu +11 more
TL;DR: The synthesis of (+)-calanolide A, an anti-HIV-1 agent, is described, which was resolved by a lipase-catalyzed acylation reaction of compound 2 stereoselectively produced the desired syn diastereomer.
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Synthesis and antiviral activities of fluorinated acyclic nucleoside phosphonates
TL;DR: In this article, a series of acyclic nucleoside phosphonates possessing the α-fluoro(phosphoryl)methoxy group were prepared by coupling of F-PME or F-HPMP derivatives with the corresponding purine or pyrimidine nucleic bases under either modified Mitsunobu conditions or base-catalyzed alkylation conditions.
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Introduction of α-fluorophosphonomethyl ether functionality and its application to the synthesis of fluorinated acyclic phosphonate nucleosides
TL;DR: In this paper, the α-fluorophosphonomethyl ether functionality was achieved by electrophilic fluorination of the corresponding PDE carbanion, and the result was shown to be a novel fluorinated acyclic phosphonate nucleosides.
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An improved synthesis of 9-[2-(diethoxyphosphonomethoxy)ethyl]adenine and its analogues with other purine bases utilizing the mitsunobu reaction
TL;DR: Unprotected adenine, 6-chloropurine, 2-amino-6-chluropurine and 2-(diethoxyphosphonomethoxy)ethanol under Mitsunobu reaction conditions to provide acyclic phosphonate nucleotide analogues which are intermediates for antiviral agents such as PMEA as discussed by the authors.