T
Thitima Pengsuparp
Researcher at Chulalongkorn University
Publications - 32
Citations - 1566
Thitima Pengsuparp is an academic researcher from Chulalongkorn University. The author has contributed to research in topics: Programmed cell death & Reverse transcriptase. The author has an hindex of 19, co-authored 32 publications receiving 1431 citations. Previous affiliations of Thitima Pengsuparp include University of Illinois at Chicago.
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Journal ArticleDOI
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora
Yuh-Meei Lin,Herbert M. Anderson,Michael T. Flavin,Yeah-Huei S. Pai,Eugenia Mata-Greenwood,Thitima Pengsuparp,John M. Pezzuto,Raymond F. Schinazi,Stephen H. Hughes,Fa-Ching Chen +9 more
TL;DR: The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 microM and 170 microM, respectively.
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Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy- 2-methylbutan-2-ol, cyclization, and Luche reduction.
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Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase
Han-Dong Sun,Sheng-Xiang Qiu,Long-Ze Lin,Zong-yu Wang,Zhong-wen Lin,Thitima Pengsuparp,John M. Pezzuto,Harry H. S. Fong,Geoffrey A. Cordell,Norman R. Farnsworth +9 more
TL;DR: Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays and its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling.
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Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.
Thitima Pengsuparp,L. Cai,Howard L. Constant,Harry H. S. Fong,Long-Ze Lin,A. D. Kinghorn,John M. Pezzuto,Geoffrey A. Cordell,K. Ingólfsdóttir,Hans-Ulrich Wagner +9 more
TL;DR: The mechanism of action of 1 beta-hydroxyaleuritolic acid 3-p-Hydroxybenzoate and protolichesterinic acid as HIV-1 RT inhibitors involves nonspecific binding to the enzyme at nonsubstrate binding sites, whereas swertifrancheside inhibits enzyme activity by binding toThe template-primer.
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Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells
TL;DR: Co-treatment of cisplatin with autophagy inducer, trifluorperazine, could resensitize H460/cis cells to cisPlatin-induced cell death, suggesting the role of autophagosome formation detected by acridine orange staining was dramatically reduced in the resistant cells, suggestingThe role of Autophagy in attenuating of cis platin- induced cell death.