Z
Ze-Qi Xu
Researcher at University of Illinois at Chicago
Publications - 33
Citations - 648
Ze-Qi Xu is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Phosphonate & Calanolide A. The author has an hindex of 12, co-authored 33 publications receiving 616 citations. Previous affiliations of Ze-Qi Xu include Southern Research Institute.
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Journal ArticleDOI
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy- 2-methylbutan-2-ol, cyclization, and Luche reduction.
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Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis
Ze-Qi Xu,William W. Barrow,William J. Suling,Louise Westbrook,Esther W. Barrow,Yuh-Meei Lin,Michael T. Flavin +6 more
TL;DR: In this article, the anti-HIV-1 agent (+)-calanolide A was found to be active against all of the strains of Mycobacterium tuberculosis tested, including those resistant to the standard antitubercular drugs.
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Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).
David E. Zembower,Shuyuan Liao,M. T. Flavin,Ze-Qi Xu,Tracy L. Stup,Robert W. Buckheit,A. Khilevich,and Aye Aye Mar,Abram K. Sheinkman +8 more
TL;DR: (+)-Calanolide A is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1), which was isolated from an extract of Calophyllum lanigerum, along with seven related compounds, which were confirmed to be inhibitors of HIV-1reverse transcriptase.
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Novel approach for synthesis of (±)-calanolide a and its anti-HIV activity
Alla Kucherenko,Michael T. Flavin,William A. Boulanger,Albert Khilevich,Robert L. Shone,John D. Rizzo,Abram Kivovich Sheinkman,Ze-Qi Xu +7 more
TL;DR: The key intermediate, chromene 5, was synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan- 2-ol.
Journal ArticleDOI
Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products
Albert Khilevich,Aye Aye Mar,Michael T. Flavin,John D. Rizzo,Lin Lin,S. Dzekhtser,D. Brankovic,Heping Zhang,Wei Chen,Shuyuan Liao,David E. Zembower,Ze-Qi Xu +11 more
TL;DR: The synthesis of (+)-calanolide A, an anti-HIV-1 agent, is described, which was resolved by a lipase-catalyzed acylation reaction of compound 2 stereoselectively produced the desired syn diastereomer.