S
Stephen H. Hughes
Researcher at National Institutes of Health
Publications - 124
Citations - 6423
Stephen H. Hughes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Reverse transcriptase & Integrase. The author has an hindex of 37, co-authored 124 publications receiving 5791 citations. Previous affiliations of Stephen H. Hughes include University of Illinois at Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Frank Maldarelli,Xiaolin Wu,Ling Su,Francesco R. Simonetti,Wei Shao,Shawn Hill,Jonathan Spindler,A. L. Ferris,John W. Mellors,Mary F. Kearney,John M. Coffin,Stephen H. Hughes +11 more
TL;DR: Findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells, and may determine the size of the latent reservoir.
Journal ArticleDOI
Reprogramming human T cell function and specificity with non-viral genome targeting
Theodore L. Roth,Cristina Puig-Saus,Ruby Yu,Ruby Yu,Eric Shifrut,Eric Shifrut,Julia Carnevale,P. Jonathan Li,P. Jonathan Li,Joseph Hiatt,Justin Saco,Paige Krystofinski,Han Li,Victoria Tobin,Victoria Tobin,David N. Nguyen,David N. Nguyen,Michael R. Lee,Amy L. Putnam,Andrea L. Ferris,Jeff W. Chen,Jean Nicolas Schickel,Laurence Pellerin,David Carmody,Gorka Alkorta-Aranburu,Daniela del Gaudio,Hiroyuki Matsumoto,Montse Morell,Ying Mao,Min Cho,Rolen M. Quadros,Channabasavaiah B. Gurumurthy,Baz Smith,Michael Haugwitz,Stephen H. Hughes,Jonathan S. Weissman,Kathrin Schumann,Kathrin Schumann,Jonathan H. Esensten,Andrew P. May,Alan Ashworth,Gary M. Kupfer,Siri Atma W. Greeley,Rosa Bacchetta,Eric Meffre,Maria Grazia Roncarolo,Neil Romberg,Neil Romberg,Kevan C. Herold,Antoni Ribas,Manuel D. Leonetti,Alexander Marson +51 more
TL;DR: A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.
Journal ArticleDOI
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
Kalyan Das,Arthur D. Clark,Paul J. Lewi,Jan Heeres,Marc René De Jonge,Lucien Maria Henricus Koymans,H. Maarten Vinkers,Frederik Frans Desire Daeyaert,Donald William Ludovici,Michael J. Kukla,Bart De Corte,Robert W. Kavash,Chih Y. Ho,Hong Ye,Mark A. Lichtenstein,Koen Andries,Rudi Pauwels,Marie Pierre de Béthune,Paul L. Boyer,Patrick K. Clark,Stephen H. Hughes,Paul A. J. Janssen,Eddy Arnold +22 more
TL;DR: Structural studies showed that this inhibitor and other diarylpyrimidine (DAPY) analogues can adapt to changes in the NNRTI-binding pocket in several ways, and adaptations appear to be critical for potency against wild-type and a wide range of drug-resistant mutant HIV-1 RTs.
Journal ArticleDOI
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
TL;DR: The bioassay system was shown to be generally applicable to both pure natural products and plant extracts, and proved useful in directing an isolation procedure with Plumeria rubra to yield fulvoplumierin as an active compound.
Journal ArticleDOI
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora
Yuh-Meei Lin,Herbert M. Anderson,Michael T. Flavin,Yeah-Huei S. Pai,Eugenia Mata-Greenwood,Thitima Pengsuparp,John M. Pezzuto,Raymond F. Schinazi,Stephen H. Hughes,Fa-Ching Chen +9 more
TL;DR: The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 microM and 170 microM, respectively.