R
Robert M. Porsch
Researcher at University of Hong Kong
Publications - 15
Citations - 612
Robert M. Porsch is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Covariate & Copy-number variation. The author has an hindex of 7, co-authored 15 publications receiving 327 citations. Previous affiliations of Robert M. Porsch include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
Polygenic scores via penalized regression on summary statistics
TL;DR: It is shown that pseudovalidation often resulted in prediction accuracy that is comparable to using a dataset with validation phenotype and was clearly superior to the conservative option of setting the tuning parameter of lassosum to its lowest value, and it was also substantially faster and more accurate than the recently proposed LDpred.
Posted ContentDOI
Polygenic scores via penalized regression on summary statistics
TL;DR: It is shown that pseudovalidation often resulted in prediction accuracy that is comparable to using a dataset with validation phenotype and was clearly superior to the conservative option of setting the tuning parameter of lassosum to its lowest value, and it was also substantially faster and more accurate than the recently proposed LDpred.
Journal ArticleDOI
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Clara S. Tang,He Zhang,Chloe Y Y Cheung,Ming Xu,Jenny C. Y. Ho,Wei Zhou,Stacey S. Cherny,Stacey S. Cherny,Yan Zhang,Oddgeir L. Holmen,Ka-Wing Au,Haiyi Yu,Lin Xu,Jia Jia,Robert M. Porsch,Lijie Sun,Weixian Xu,Huiping Zheng,Lai-Yung Wong,Yiming Mu,Jingtao Dou,Carol H.Y. Fong,Shuyu Wang,Xueyu Hong,Liguang Dong,Yanhua Liao,Jiansong Wang,Levina S. M. Lam,Xi Su,Hua Yan,Min-Lee Yang,Jin Chen,Chung-Wah Siu,Chung-Wah Siu,Gaoqiang Xie,YC Woo,Yangfeng Wu,Kathryn C.B. Tan,Kathryn C.B. Tan,Kristian Hveem,Bernard M.Y. Cheung,Bernard M.Y. Cheung,Sebastian Zöllner,Aimin Xu,Y. Eugene Chen,Chaoqiang Jiang,Youyi Zhang,Tai Hing Lam,Santhi K. Ganesh,Yong Huo,Pak C. Sham,Pak C. Sham,Karen S.L. Lam,Karen S.L. Lam,Cristen J. Willer,Hung-Fat Tse,Hung-Fat Tse,Wei Gao +57 more
TL;DR: It is demonstrated that exome-wide genotyping on samples of non-European ancestry can identify additional population-specific possible causal variants, shedding light on novel lipid biology and CAD.
Journal ArticleDOI
Longitudinal heritability of childhood aggression
Robert M. Porsch,Christel M. Middeldorp,Stacey S. Cherny,Stacey S. Cherny,Eva Krapohl,Catharina E. M. van Beijsterveldt,Anu Loukola,Tellervo Korhonen,Tellervo Korhonen,Lea Pulkkinen,Robin P. Corley,Soo Hyun Rhee,Jaakko Kaprio,Jaakko Kaprio,Richard R. Rose,John K. Hewitt,Pak C. Sham,Pak C. Sham,Robert Plomin,Dorret I. Boomsma,Meike Bartels +20 more
TL;DR: In this paper, genetic and environmental contributions to the variation and longitudinal stability in childhood aggressive behavior were assessed in two large twin cohorts, the Netherlands Twin Register (NTR), and the Twins Early Development Study (TEDS; United Kingdom).
Journal ArticleDOI
The Genes We Inherit and Those We Don’t: Maternal Genetic Nurture and Child BMI Trajectories
TL;DR: A simplified model for estimating genetic nurture effects is introduced and it is shown that this method provides unbiased estimates and offers an increase in power to detect genetic nurture of up to 1/3 greater than that of previous methods.