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Robert T. Kinobe
Researcher at James Cook University
Publications - 53
Citations - 2280
Robert T. Kinobe is an academic researcher from James Cook University. The author has contributed to research in topics: Heme oxygenase & Biology. The author has an hindex of 18, co-authored 44 publications receiving 1918 citations. Previous affiliations of Robert T. Kinobe include Queen's University & Australian Institute of Tropical Health and Medicine.
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Journal ArticleDOI
Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain
TL;DR: The distribution of the 1,25-dihydroxyvitamin D3 receptor (VDR), and 1α-hydroxylase (1α-OHase), the enzyme responsible for the formation of the active vitamin in the human brain, was reported for the first time.
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Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.
Gheorghe Roman,John G. Riley,Jason Z. Vlahakis,Robert T. Kinobe,James F. Brien,Kanji Nakatsu,Walter A. Szarek +6 more
TL;DR: A series of 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutane derivatives substituted with halogens in the phenyl ring were synthesized and evaluated as novel inhibitors of heme oxygenase which are structurally distinct from metalloporphyrins.
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Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Jason Z. Vlahakis,Robert T. Kinobe,Raymond J. Bowers,James F. Brien,Kanji Nakatsu,Walter A. Szarek +5 more
TL;DR: These imidazole-dioxolane compounds are the first of their type known to exhibit this isozyme-selective HO inhibition and had substantially less inhibitory potency toward HO-2, the constitutive isozyme.
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Selectivity of imidazole–dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms
Robert T. Kinobe,Jason Z. Vlahakis,Hendrik J. Vreman,David K. Stevenson,James F. Brien,Walter A. Szarek,Kanji Nakatsu +6 more
TL;DR: Imidazole–dioxolanes are identified that are able to inhibit microsomal HO in vitro with high selectivity for HO‐1 compared to HO‐2, and little or no effect on the activities of neuronal NOS and sGC.
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Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction
Xiaoli Liu,Jeremy A. Simpson,Keith R. Brunt,Christopher A. Ward,Sean Hall,Robert T. Kinobe,Valérie F. Barrette,M. Yat Tse,Stephen C. Pang,Alok S. Pachori,Victor J. Dzau,Kofo O. Ogunyankin,Luis G. Melo +12 more
TL;DR: Results suggest that preemptive HO-1 gene delivery may be useful as a therapeutic strategy to reduce post-MI LV remodeling and heart failure.