R
Robert V. Considine
Researcher at Indiana University
Publications - 214
Citations - 27318
Robert V. Considine is an academic researcher from Indiana University. The author has contributed to research in topics: Leptin & Adipose tissue. The author has an hindex of 69, co-authored 207 publications receiving 26242 citations. Previous affiliations of Robert V. Considine include East Carolina University & University of Virginia.
Papers
More filters
Journal ArticleDOI
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Robert V. Considine,Madhur K. Sinha,Mark L. Heiman,Aidas Kriauciunas,Thomas W. Stephens,Mark R. Nyce,Joanna P. Ohannesian,Cheryl C. Marco,Linda J. McKee,Thomas L. Bauer,Jose F. Caro +10 more
TL;DR: Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
Journal ArticleDOI
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman,Dmitry O. Traktuev,Jingling Li,Stephanie Merfeld-Clauss,Constance J. Temm-Grove,Jason E. Bovenkerk,Carrie L. Pell,Brian H. Johnstone,Robert V. Considine,Keith L. March +9 more
TL;DR: The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
Journal ArticleDOI
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Jose F. Caro,Jerzy W. Kolaczynski,Mark R. Nyce,Joanna P. Ohannesian,Irina Opentanova,Warren H Goldman,Richard B. Lynn,Peili Zhang,Madhur K. Sinha,Robert V. Considine +9 more
TL;DR: The data suggest that leptin enters the brain by a saturable transport system, lower in obese individuals, and may provide a mechanism for leptin resistance.
Journal ArticleDOI
Leptin: The Tale of an Obesity Gene
TL;DR: The discovery of a "fat-melting hormone" named leptin by Friedman raised the hopes of one-third of the U.S. population that there is a simple solution to cure their obesity and the concept of leptin resistance has since been extended to other studies in humans and to the animal models of obesity.
Journal ArticleDOI
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
Antonio Vidal-Puig,Robert V. Considine,Mercedes Jimenez-Linan,Ariel Werman,Walter J. Pories,Jose F. Caro,Jeffrey S. Flier +6 more
TL;DR: Human PPAR gamma mRNA expression is most abundant in adipose tissue, but lower level expression of both splice variants is seen in skeletal muscle; to an extent that is unlikely to be due to adipose contamination.