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Stephanie Merfeld-Clauss
Researcher at Indiana University
Publications - 27
Citations - 3938
Stephanie Merfeld-Clauss is an academic researcher from Indiana University. The author has contributed to research in topics: Adipose tissue & Stromal cell. The author has an hindex of 13, co-authored 25 publications receiving 3682 citations. Previous affiliations of Stephanie Merfeld-Clauss include University of Florida & Veterans Health Administration.
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Journal ArticleDOI
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman,Dmitry O. Traktuev,Jingling Li,Stephanie Merfeld-Clauss,Constance J. Temm-Grove,Jason E. Bovenkerk,Carrie L. Pell,Brian H. Johnstone,Robert V. Considine,Keith L. March +9 more
TL;DR: The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
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A Population of Multipotent CD34-Positive Adipose Stromal Cells Share Pericyte and Mesenchymal Surface Markers, Reside in a Periendothelial Location, and Stabilize Endothelial Networks
Dmitry O. Traktuev,Stephanie Merfeld-Clauss,Jingling Li,Mikhail G. Kolonin,Wadih Arap,Renata Pasqualini,Brian H. Johnstone,Keith L. March,Keith L. March +8 more
TL;DR: The results demonstrate for the first time that the majority of adipose-derived adherent CD34+ cells are resident pericytes that play a role in vascular stabilization by mutual structural and functional interaction with endothelial cells.
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Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells
Dmitry O. Traktuev,Daniel N. Prater,Stephanie Merfeld-Clauss,Aravind Sanjeevaiah,M. Reza Saadatzadeh,Michael P. Murphy,Brian Johnstone,David A. Ingram,Keith L. March +8 more
TL;DR: This study is the first to demonstrate prompt and consistent assembly of a vascular network by human ASCs and endothelial cells and vascularization by these cells of parenchymal cells in implants.
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Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation.
TL;DR: It is demonstrated that ASCs have a profound potential to stimulate morphogenesis of ECs into branching networks of cord structures and the vasculogenesis-promoting potential of ASCs depends on interaction with ECs involving contact and likely bi-directional interaction, resulting in modulated secretion of cytokines and ECM proteins.
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IFATS Collection: Adipose Stromal Cell Differentiation Is Reduced by Endothelial Cell Contact and Paracrine Communication: Role of Canonical Wnt Signaling
Gangaraju Rajashekhar,Dmitry O. Traktuev,William Roell,Brian H. Johnstone,Stephanie Merfeld-Clauss,Bruce W. Van Natta,Elliot D. Rosen,Keith L. March,Matthias Clauss +8 more
TL;DR: The relationship in adipose tissue between ASC and EC in the perivascular niche is defined, in which the latter act to repress adipogenesis, thereby stabilizing vasculature.