P
Paul L. McNeil
Researcher at Georgia Regents University
Publications - 81
Citations - 10057
Paul L. McNeil is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Plasma membrane repair & Cell membrane. The author has an hindex of 52, co-authored 81 publications receiving 9476 citations. Previous affiliations of Paul L. McNeil include University of Sydney & Harvard University.
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Journal ArticleDOI
Defective membrane repair in dysferlin-deficient muscular dystrophy
Dimple Bansal,Katsuya Miyake,Steven S. Vogel,Séverine Groh,Chien-Chang Chen,Roger A. Williamson,Paul L. McNeil,Kevin P. Campbell +7 more
TL;DR: It is shown that disruption of the muscle membrane repair machinery is responsible for dysferlin-deficient muscle degeneration, and the importance of this basic cellular mechanism of membrane resealing in human disease is highlighted.
Journal Article
Disruptions of muscle fiber plasma membranes. Role in exercise-induced damage.
Paul L. McNeil,Robert Khakee +1 more
TL;DR: It is proposed that membrane disruptions provide a route into and out of myofiber cytoplasm distinct from the conventional, membrane-bounded routes of endo- and exocytosis, and therefore may be of importance both technically, as a route for introducing foreign genes into muscle cells, and biologically, as an route for release of the growth factor, basic fibroblast growth factor.
Journal ArticleDOI
Plasma membrane disruption: repair, prevention, adaptation
TL;DR: Prevention of disruption can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed, and disease results from failure of either the preventive or resealing mechanisms.
Journal ArticleDOI
Growth factors are released by mechanically wounded endothelial cells.
TL;DR: It is concluded that one biologically relevant route of release of basic fibroblast growth factor could be directly through mechanically induced membrane disruptions of endothelial cells growing in vivo and in vitro.
Journal ArticleDOI
An emergency response team for membrane repair.
Paul L. McNeil,Tom Kirchhausen +1 more
TL;DR: On demand, rapid Ca2+-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and it is proposed that this emergency-based fusion differs fundamentally from other rapid, triggered fusion reactions.