R
Robert Westphal
Researcher at Forschungszentrum Jülich
Publications - 18
Citations - 398
Robert Westphal is an academic researcher from Forschungszentrum Jülich. The author has contributed to research in topics: Phenylacetylcarbinol & Lyase. The author has an hindex of 8, co-authored 18 publications receiving 351 citations.
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Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials
Torsten Sehl,Helen C. Hailes,John M. Ward,Rainer Wardenga,Eric von Lieres,Heike Offermann,Robert Westphal,Martina Pohl,Dörte Rother +8 more
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Engineering stereoselectivity of ThDP‐dependent enzymes
Helen C. Hailes,Dörte Rother,Michael Müller,Robert Westphal,John M. Ward,Jürgen Pleiss,Constantin Vogel,Martina Pohl +7 more
TL;DR: This review covers recent studies and the mechanistic understanding of stereoselective C–C bond forming thiamine diphosphate‐dependent enzymes, which has been guided by structure–function analyses based on mutagenesis studies and from influences of different substrates and organic co‐solvents on stereoselectedivity.
Journal ArticleDOI
A tailor-made chimeric thiamine diphosphate dependent enzyme for the direct asymmetric synthesis of (S)-benzoins.
Robert Westphal,Constantin Vogel,Carlo Schmitz,Jürgen Pleiss,Michael Müller,Martina Pohl,Dörte Rother +6 more
TL;DR: This work has constructed a chimeric enzyme, which catalyzes the synthesis of various (S)-benzoins with excellent enantiomeric excess (>99%) and very good conversion.
Journal ArticleDOI
Zwei Schritte in einem Reaktionsgefäß: Enzymkaskaden zur selektiven Synthese von Nor(pseudo)ephedrin aus kostengünstigen Ausgangsmaterialien
Torsten Sehl,Helen C. Hailes,John M. Ward,Rainer Wardenga,Eric von Lieres,Heike Offermann,Robert Westphal,Martina Pohl,Dörte Rother +8 more
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(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones
Robert Westphal,Simon Waltzer,Ursula Mackfeld,Michael Widmann,Jürgen Pleiss,Maryam Beigi,Michael Müller,Dörte Rother,Martina Pohl +8 more
TL;DR: It is reported the first rationally designed (S)-selective MenD from E. coli for the synthesis of functionalized α-hydroxy ketones by mutation of two amino acids in the active site stereoselectivity of the (R)- selective EcMenD.