Roberto Anacardio

TL;DR: Structural and biochemical data are consistent with a noncompetitive allosteric mode of interaction between CXCR1 and Repertaxin, which, by locking CX CR1 in an inactive conformation, prevents signaling.

TL;DR: In the search for a new class of bone‐sparing agents for treating osteopenic disorders, it was hypothesized that tartronic acid derivatives, sharing the chemical characteristics both of bisphosphonates and of Gla residues contained in matrix proteins such as osteocalcin, could positively affect bone metabolism.

TL;DR: Results indicate that CXCR1/CXCR2 and their ligands have a role in the inflammatory component of cerebral ischemia, and that these pathways represent an important pharmacological target.

TL;DR: In this article, an optimized cost-effective synthesis of the new antitussive drug, DF1012, is reported. The new synthetic route to the key intermediate DF1005 is based on the unusual deprotection step of the 1-tert-butyl-3-cyano-7-azaindole intermediate.

TL;DR: A sensitive and selective liquid chromatographic method coupled with tandem mass spectrometry was developed and validated for the quantification of methanesulfonamide (MSA) in human urine after intravenous administration of reparixin to healthy volunteers.