Robin J. Rosenfeld

TL;DR: The spectroscopic response of DXR and DNM to their surroundings in several systems, including solvents of differing dielectric constant, aqueous solutions of varying pH or fluorophore concentration, and the reverse micellar system of AOT/heptane/water with a range of doxorubicin concentrations is delineated.

TL;DR: The anchored plasticity approach, which anchor an inhibitor core in a conserved binding pocket, then extend rigid bulky substituents towards remote specificity pockets, accessible upon conformational changes of flexible residues, exemplifies general principles for the design of selective enzyme inhibitors that overcome strong active-site conservation.

TL;DR: The results indicate that the three NOS isozymes, despite their general structural similarity, differ markedly in their strengths, interfaces, and in how l-Arg and H4B influence their formation and stability.

TL;DR: It is suggested that 5-methyltetrahydrofolate directly interacts with nitric oxide synthase to promoteNitric oxide (vs. superoxide) production and improve endothelial function and may represent an important strategy for intervention aimed at improving tetraydrobiopterin bioavailability.

TL;DR: The correlation between three‐dimensional domain swapping of the N‐terminal hook and metal ion release with disulfide formation may impact inducible nitric oxide synthase (i)NOS stability and regulation in vivo.