R
Roderick R. McInnes
Researcher at University of Toronto
Publications - 115
Citations - 9890
Roderick R. McInnes is an academic researcher from University of Toronto. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 47, co-authored 115 publications receiving 9504 citations. Previous affiliations of Roderick R. McInnes include Canadian Institutes of Health Research & Ontario Veterinary College.
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Journal ArticleDOI
Retinal Stem Cells in the Adult Mammalian Eye
Vincent Tropepe,Brenda L. K. Coles,Bernard J. Chiasson,D. Jonathan Horsford,Andrew J. Elia,Roderick R. McInnes,Derek van der Kooy +6 more
TL;DR: Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.
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Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
Carol L. Freund,Cheryl Y. Gregory-Evans,Takahisa Furukawa,Myrto Papaioannou,Jens Looser,Lynda Ploder,James Bellingham,David Ng,Jo Anne Herbrick,Alessandra M.V. Duncan,Stephen W. Scherer,Lap-Chee Tsui,Aphrodite Loutradis-Anagnostou,Samuel G. Jacobson,Constance L. Cepko,Shomi S. Bhattacharya,Roderick R. McInnes +16 more
TL;DR: It is shown that mutations in a novel photoreceptor-specific homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13 and that CRX is essential for the maintenance of mammalian photoreceptors.
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Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
Margit Burmeister,Jakub Novak,Mei Ying Liang,Sharmila Basu,Lynda Ploder,Norman L. Hawes,Danka Vidgen,F. Hoover,Daniel Goldman,Vitauts I. Kalnins,Thomas H. Roderick,Benjamin A. Taylor,Mark H. Hankin,Roderick R. McInnes +13 more
TL;DR: It is shown that mice carrying the orJ allele have a premature stop codon in the homeobox of the Chx1O gene, a gene expressed at high levels in uncommitted retinal progenitor cells and mature bipolar cells, which indicates that Chx10 is an essential component in the network of genes required for the development of the mammalian eye.
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Facile isolation and the characterization of human retinal stem cells
Brenda L. K. Coles,Brigitte Angénieux,Tomoyuki Inoue,Katia Del Rio-Tsonis,Jason R. Spence,Roderick R. McInnes,Yvan Arsenijevic,Derek van der Kooy +7 more
TL;DR: The transplanted dissociated human retinal sphere cells, containing both stem cells and progenitors, into the eyes of postnatal day 1 NOD/SCID mice and embryonic chick eyes were able to survive, migrate, integrate, and differentiate into the neural retina, especially as photoreceptors.
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Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
Sarah E. Ross,Alan R. Mardinly,Alejandra E. McCord,Jonathan Zurawski,Sonia Cohen,Cynthia C. Jung,Linda Hu,Stephanie I. Mok,Anar Shah,Erin M. Savner,Christos S. Tolias,Roman Corfas,Suzhen Chen,Perrine Inquimbert,Yi Xu,Roderick R. McInnes,Frank L. Rice,Gabriel Corfas,Qiufu Ma,Clifford J. Woolf,Clifford J. Woolf,Michael E. Greenberg +21 more
TL;DR: Itch is the least well understood of all the somatic senses, and the neural circuits that underlie this sensation are poorly defined, and it is suggested that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus.