R
Rodolfo Lavilla
Researcher at University of Barcelona
Publications - 168
Citations - 4354
Rodolfo Lavilla is an academic researcher from University of Barcelona. The author has contributed to research in topics: Indole test & Pyridinium. The author has an hindex of 31, co-authored 162 publications receiving 3751 citations. Previous affiliations of Rodolfo Lavilla include Park University.
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Journal ArticleDOI
Heterocycles as key substrates in multicomponent reactions: the fast lane towards molecular complexity.
Nicolas Isambert,Rodolfo Lavilla +1 more
TL;DR: Several approaches which allow the construction of complex heterocyclic compounds from simple starting materials using this principle have been analyzed and show relevant examples of such transformations.
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New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues
Lorena Mendive-Tapia,Sara Preciado,Jesús García,Rosario Ramón,Nicola Kielland,Fernando Albericio,Rodolfo Lavilla +6 more
TL;DR: A synthetic strategy for the preparation of unique constrained peptides featuring a covalent bond between tryptophan and phenylalanine or tyrosine residues through an intramolecular palladium-catalysed C–H activation process is described.
Journal ArticleDOI
Chemical and Biological Aspects of Narcissus Alkaloids
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Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds
Pelayo Camps,Xavier Formosa,Carles Galdeano,Diego Muñoz-Torrero,Lorena Ramírez,Elena Gómez,Nicolas Isambert,Rodolfo Lavilla,Albert Badia,M. Victòria Clos,Manuela Bartolini,Francesca Mancini,Vincenza Andrisano,Mariana P. Arce,M. Isabel Rodríguez-Franco,Oscar Huertas,Thomai Dafni,F. Javier Luque +17 more
TL;DR: Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors that retain the potent and selective human AChE inhibitory activity of the parent 6-chlorotacrine while exhibiting a significant in vitro inhibitoryActivity toward the AChe-induced and self-induced Abeta aggregation and toward BACE-1, as well as ability to enter the central nervous system, which makes them promising anti-Alzheimer lead compounds.