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Recent developments in the chemistry of dihydropyridines
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This article is published in Journal of The Chemical Society-perkin Transactions 1.The article was published on 2002-04-26. It has received 325 citations till now.read more
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Dearomatization Strategies in the Synthesis of Complex Natural Products
Stéphane P. Roche,John A. Porco +1 more
TL;DR: This Review highlights recent developments concerning dearomatization, a powerful strategy for the total synthesis of architecturally complex natural products wherein planar, aromatic scaffolds are converted to three-dimensional molecular architectures.
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Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles
Jie Yu,Feng Shi,Liu-Zhu Gong +2 more
TL;DR: A detailed investigation of several MCRs catalyzed by chiral phosphoric acids that lead to the production of structurally diverse nitrogenous heterocycles is presented, including Biginelli and Biginelli-like reactions; 1,3-dipolar cycloadditions; aza Diels-Alder reactions; and some other cyclization reactions.
Journal ArticleDOI
Recent developments in asymmetric multicomponent reactions.
TL;DR: Significantly broadened scopes, new techniques, more environmentally benign methods and entirely novel MCRs reflect the increasingly inventive paths that synthetic chemist follow in this field of asymmetric multicomponent reactions.
Journal ArticleDOI
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines
TL;DR: Stereoselective Addition to N-Activated Pyridines James A. Bull, Guillaume Pelletier,† and Andre ́ B. Charette are credited for this work.
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Enantioselective Organocatalytic Hydride Reduction
TL;DR: The first enantioselective organocatalytic hydride reduction has been accomplished and the implementation of geometrically impure enals in this operationally simple protocol.
References
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Approaches to combinatorial synthesis of heterocycles : a solid-phase synthesis of 1,4-dihydropyridines
TL;DR: This new solid-phase synthesis has been applied to the preparation of several bioactive DHPs and is designed to be amenable to the “split and pool” protocol for combinatorial library synthesis.
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Selective One-Electron and Two-Electron Reduction of C60 with NADH and NAD Dimer Analogues via Photoinduced Electron Transfer
Shunichi Fukuzumi,Tomoyoshi Suenobu,Matthias Patz,Takeomi Hirasaka,Shinobu Itoh,Mamoru Fujitsuka,Osamu Ito +6 more
TL;DR: In this paper, the selective one-electron reduction of C60 to C60•- is attained through photoinduced electron transfer from an NADH analogue, 1-benzyl-1,4-dihydronicotinamide (BNAH), and the dimer analogue [(BNA)2] to the triplet excited state of C 60.
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Carbon-carbon bond-forming solid-phase reactions. Part II.
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NAD+-Dependent Enzyme Electrodes: Electrical Contact of Cofactor-Dependent Enzymes and Electrodes
TL;DR: The bioelectrocatalyzed process involves the PQQ-mediated oxidation of the immobilized NADH in the presence of Ca2+ ions and the biocatalyst dissociates to the electrolyte solution.
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Computational Studies of the Mechanism for Proton and Hydride Transfer in Liver Alcohol Dehydrogenase
TL;DR: In this paper, computational studies were conducted to elucidate the mechanism of the oxidation of benzyl alcohol by liver alcohol dehydrogenase (LADH) using a 148-atom model of the active site.