R
Rodrigo Díaz-Ruiz
Researcher at National Autonomous University of Mexico
Publications - 5
Citations - 608
Rodrigo Díaz-Ruiz is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Mitochondrion & Oxidative phosphorylation. The author has an hindex of 5, co-authored 5 publications receiving 541 citations. Previous affiliations of Rodrigo Díaz-Ruiz include Ludwig Institute for Cancer Research.
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Journal ArticleDOI
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression.
TL;DR: This paper will review common metabolic properties of the fermenting yeast Saccharomyces cerevisiae and tumor cells as well as the possible origins of the Crabtree and Warburg effects.
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Mitochondrial Oxidative Phosphorylation Is Regulated by Fructose 1,6-Bisphosphate A POSSIBLE ROLE IN CRABTREE EFFECT INDUCTION?
Rodrigo Díaz-Ruiz,Nicole Avéret,Daniela Araiza,Benoît Pinson,Salvador Uribe-Carvajal,Anne Devin,Michel Rigoulet +6 more
TL;DR: It is proposed that F16bP regulates oxidative phosphorylation and thus participates in the establishment of the Crabtree effect.
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Anaplerosis in cancer: Another step beyond the warburg effect
TL;DR: The implications of an active anaplerosis in cancer are analyzed, experimental evidence showing the relevance of these metabolic routes in tumor physiology is discussed and two pathways that function in an anaplerotic fashion are discussed.
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Biotin deprivation impairs mitochondrial structure and function and has implications for inherited metabolic disorders.
Estefanía Ochoa-Ruiz,Rodrigo Díaz-Ruiz,Alain de J. Hernandez-Vazquez,Isabel Ibarra-González,Alma Ortiz-Plata,Daniel Rembao,Daniel Ortega-Cuellar,Benoit Viollet,Benoit Viollet,Benoit Viollet,Salvador Uribe-Carvajal,José Ahmed Corella,Antonio Velázquez-Arellano +12 more
TL;DR: It is shown that in rats and cultured cells it is the result of reduced TCA cycle flow, partly due to deficient anaplerotic biotin-dependent pyruvate carboxylase, accompanied by diminished flow through the electron transport chain, which implies core mechanisms of energy deficit in several inherited metabolic disorders.
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Oxidative phosphorylation in Debaryomyces hansenii: Physiological uncoupling at different growth phases
TL;DR: Physiological uncoupling of mitochondrial oxidative phosphorylation (OxPhos) was studied in Debaryomyces hansenii and loss of NAD(+) from the matrix through an open MUC is proposed as an additional mechanism to uncouple OxPhos.