Roger D. Porsolt

TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.

TL;DR: This simple behavioral procedure has since become a useful test for screening novel antidepressants in rats and is presented in this unit and an equivalent procedure in the mouse is also described along with a "dry” version of the test where immobility is induced simply by suspending the mouse by the tail.

TL;DR: Important differences exist between strains in both the amount of immobility observed and the effects of imipramine, and strain differences should be taken into account in attempts to replicate results from one laboratory to another.

TL;DR: It was concluded that immobility depended primarily on the activity of central catecholamines but that caution was required before ascribingimmobility exclusively to activity within a single system.

TL;DR: In this article, a potent nAChR ligand called ABT-594 was developed that has antinociceptive properties equal in efficacy to those of morphine across a series of diverse animal models of acute thermal, persistent chemical, and neuropathic pain states.