Showing papers in "European Journal of Pharmacology in 1979"

TL;DR: It was concluded that immobility depended primarily on the activity of central catecholamines but that caution was required before ascribingimmobility exclusively to activity within a single system.

TL;DR: 3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors, suggesting that it may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.

TL;DR: The data suggest that ZC cells receive an inhibitory GABAergic input from ZR cells that are in turn inhibited by low doses of GABA agonists, which would account for the "paradoxical" excitatory effect ofGA agonists on ZC neuron activity.

TL;DR: Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and3H-spiroperidol in the striatum is increased and in rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

TL;DR: In this paper, behavioral rating scales were developed for quantification of phencyclidine (PCP)-induced locomotor activity, stereotyped behavior, and ataxia in rats.

TL;DR: It is demonstrated that ACh, met-enkephalin, and SP act upon pharmacologically distinct receptors within the LC, and that SP has no opioid agonist or antagonist potency.

TL;DR: The existence of presynaptic autoreceptors controlling the release of 5-hydroxytryptamine from serotonergic nerve endings was investigated utilizing superfused hypothalamic synaptosomes and the central 5HT receptor blocker methiothepin counteracted the inhibitory effect of 5HT.

TL;DR: Neurotensin administered intracisternally in mice increased reaction time in the hot plate test and decreased writhing induced by acetic acid and it is suggested that the antinocisponsive effect of neurotensin results from an interaction of the peptide with neurotens in-specific receptor sites in the central nervous system.

TL;DR: It is suggested that changes in the concentration of DOPAC and HVA in rat brain are reflected by parallel changes in plasma.

TL;DR: The data indicate that clonidine-induced analgesia is not a result of an interaction at morphine receptors; but rather, common pathway(s) are present which appear to complement the agonistic interaction of each.

TL;DR: The potencies of various opiates in displacing several 3H-opiate ligands' binding to rat membranes vary depending on the nature of the ligand, and these agonists differ from the other opiate classes by possessing a relatively hydrophilic component in their C-ring moieties.

TL;DR: Results seem to make it worthwhile to test a combination of haloperidol and a serotonin antagonist in schizophrenic patients to see whether the ratio of the therapeutic effect to the extrapyramidal side effects can be improved.

TL;DR: The present data suggest that the catecholaminergic receptors in the A2-region of the NTS differ from the classic vascular alpha-receptor and that the NTS also may contain structures which can antagonize the decrease in blood pressure.

TL;DR: The findings show that stress degranulates stomach mast cells via a cholinergic pathway; released histamine from this source is largely responsbile for gastric ulceration through H1- and H2-receptor effects.

TL;DR: PGI2 infusion may protect the ischemic myocardium by reducing oxygen demand, primarily through reductions in cardiac work, and by perhaps inhibiting platelet aggregation and preserving myocardial cell integrity.

TL;DR: The data demonstrate a reversal of the initial dopamine receptor-blocking properties of trifluoperazine or thioridazine to be replaced by an enhanced response of cerebral dopamine systems while animals were still continuously receiving the drug.

TL;DR: The elevation of the nociceptive threshold after neonatal capsaicin pretreatment most likely follows from degeneration of afferent nerve fibres activated by noxious stimuli.

TL;DR: The data suggest that the analgesia produced by systemic administration of baclofen and morphine involves activation of different neuronal substrates.

TL;DR: It is suggested that the reduced 3H-apomorphine binding signifies less presynaptic receptors, which permits less autoregulation and enhanced dopamine agonist action, possibly accounting for the dopaminergic sensitization by long-term agonists.

TL;DR: The results suggest that the inhibitory effect of ATP on adrenergic neurotransmission is due to its rapid breakdown to adenosine, which acts on prejunctional P1 purinoceptors.

TL;DR: The binding of 3H-diazepam to membrane benzodiazepine receptors was examined in four inbred strains of mice and results reinforce the contention that a system involving the benzidiazepine receptor may play a role in emotional behavior.

TL;DR: It was found that a series of endogenous opioid peptides and enkephalin analogues produced dose-related analgesic effects, as determined by the tail pinch test, that were antagonized by pretreatment with naloxone 0.5 mg/kg s.c.

TL;DR: The data suggest that the NE-induced phasic contraction in Ca-free solution results from Ca release from cellular sites and that a hyperbolic relationship exists between the amount of Ca at these sites and the magnitude of the contraction.

TL;DR: Results are in good agreement with the relative potencies of the tricyclic antidepressants for blocking the uptake of noradrenaline and serotonin into central and peripheral neurons.

TL;DR: It is suggested that the modification of central 5- HT binding sites caused by long-term administration of tricylclic antidepressants is due to persistent exposure of the binding sites to elevated concentrations of 5-HT, a consequence of the5-HT uptake inhibition by the antidepressants.