R
Roger D. Rossen
Researcher at Baylor College of Medicine
Publications - 165
Citations - 8123
Roger D. Rossen is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 44, co-authored 165 publications receiving 7969 citations. Previous affiliations of Roger D. Rossen include University of Texas MD Anderson Cancer Center & Veterans Health Administration.
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Journal ArticleDOI
Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.
TL;DR: The initial demonstration that the negative inotropic effects of TNF alpha are the direct result of alterations in intracellular calcium homeostasis in the adult cardiac myocyte is provided.
Journal ArticleDOI
Inflammation in the course of early myocardial ischemia.
Mark L. Entman,Lloyd H. Michael,Roger D. Rossen,W J Dreyer,D C Anderson,Addison A. Taylor,C W Smith +6 more
TL;DR: Current evidence indicates that potential sites of therapeutic intervention will be found in pathways leading to complement activation, generation of lipid‐derived mediators, adhesion of neutrophils to endothelial cells and cardiac myocytes, and activation of neutophil secretory processes releasing proteolytic enzymes and reactive oxygen.
Journal ArticleDOI
Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion.
W J Dreyer,Lloyd H. Michael,M S West,C W Smith,R Rothlein,Roger D. Rossen,D C Anderson,Mark L. Entman +7 more
TL;DR: These data support the concepts that rapid neutrophil localization during reperfusion occurs within regions of previous myocardial ischemia and that neutrophils preferentially localize within the subendocardial region.
Journal ArticleDOI
Effects of Corticosteroids on Immunity in Man I. DECREASED SERUM IgG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE
TL;DR: In this article, the effects of methylprednisolone on immune mechanisms in the absence of other immunosuppressive agents or immunologically mediated diseases were studied and it was found that 86% of treated volunteers had significant decreases in the concentrations of serum IgG.
Journal ArticleDOI
Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients: A Randomized, Double-blind, Placebo-Controlled Efficacy Trial
Bridget Martell,Frank M. Orson,James Poling,Ellen S. Mitchell,Roger D. Rossen,Tracie J. Gardner,Thomas R. Kosten +6 more
TL;DR: Attaining high (>or=43 microg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade, so improved vaccines and boosters are needed.