J
Jonathan E. Dickerson
Researcher at University of Manchester
Publications - 23
Citations - 2380
Jonathan E. Dickerson is an academic researcher from University of Manchester. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 15, co-authored 18 publications receiving 2087 citations. Previous affiliations of Jonathan E. Dickerson include John Radcliffe Hospital & University of Oxford.
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Journal ArticleDOI
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
Gillian I. Rice,Paul R. Kasher,Gabriella Forte,Niamh M. Mannion,Sam M. Greenwood,Marcin Szynkiewicz,Jonathan E. Dickerson,Sanjeev S. Bhaskar,Massimiliano Zampini,Tracy A Briggs,Emma M. Jenkinson,Carlos A. Bacino,Roberta Battini,Enrico Bertini,Paul A. Brogan,Louise Brueton,Marialuisa Carpanelli,Corinne De Laet,Pascale de Lonlay,Mireia Del Toro,Isabelle Desguerre,Elisa Fazzi,Angels García-Cazorla,Arvid Heiberg,Masakazu Kawaguchi,Ram L. Kumar,Jean-Pierre Lin,Charles Marques Lourenço,Alison Male,Wilson Marques,Cyril Mignot,Ivana Olivieri,Simona Orcesi,Prab Prabhakar,Magnhild Rasmussen,Robert Robinson,Flore Rozenberg,Johanna L. Schmidt,Katharina Steindl,Tiong Yang Tan,William G. Van Der Merwe,Adeline Vanderver,Grace Vassallo,Emma Wakeling,Evangeline Wassmer,Elizabeth Whittaker,John H. Livingston,Pierre Lebon,Tamio Suzuki,Paul J. McLaughlin,Liam Keegan,Mary A O'Connell,Simon C. Lovell,Yanick J. Crow +53 more
TL;DR: It is shown that mutations in ADAR1 cause the autoimmune disorder Aicardi-Goutières syndrome (AGS), and it is speculated that ADar1 may limit the cytoplasmic accumulation of the dsRNA generated from genomic repetitive elements.
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A new human immunodeficiency virus derived from gorillas
Jean-Christophe Plantier,Marie Leoz,Jonathan E. Dickerson,Fabienne De Oliveira,François Cordonnier,Véronique Lemée,Florence Damond,David Robertson,François Simon +8 more
TL;DR: A new human immunodeficiency virus is identified in a Cameroonian woman and shows no evidence of recombination with other HIV-1 lineages, and seems to be the prototype of a new HIV- 1 lineage that is distinct from HIV-2 groups M, N and O.
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Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
Beverley Anderson,Paul R. Kasher,Josephine Mayer,Marcin Szynkiewicz,Emma M. Jenkinson,Sanjeev S. Bhaskar,Jill E. Urquhart,Sarah B. Daly,Jonathan E. Dickerson,James O'Sullivan,Elisabeth Oppliger Leibundgut,Joanne Muter,Ghada M H Abdel-Salem,Riyana Babul-Hirji,Peter Baxter,Andrea Berger,Andrea Berger,Luisa Bonafé,Janice E Brunstom-Hernandez,Johannes A. Buckard,David Chitayat,Wui K. Chong,Duccio Maria Cordelli,Patrick Ferreira,Joel Victor Fluss,Ewan Forrest,Emilio Franzoni,Caterina Garone,Caterina Garone,Simon Hammans,Gunnar Houge,Imelda Hughes,Sébastien Jacquemont,Pierre-Yves Jeannet,Rosalind J. Jefferson,Ram L. Kumar,Georg Kutschke,Staffan Lundberg,Charles Marques Lourenço,Ramesh Mehta,Sakkubai Naidu,Ken K. Nischal,Luís Catela Nunes,Katrin Õunap,Michel Philippart,Prab Prabhakar,Sarah Risen,Raphael Schiffmann,Calvin Soh,John B.P. Stephenson,Helen Stewart,Jon Stone,John Tolmie,Marjo S. van der Knaap,José Pedro Vieira,Catheline Vilain,Emma Wakeling,Vanessa Wermenbol,Andrea Whitney,Simon C. Lovell,Stefan Meyer,Stefan Meyer,John H. Livingston,Gabriela M. Baerlocher,Graeme C.M. Black,Gillian I. Rice,Yanick J. Crow +66 more
TL;DR: Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells.
Journal ArticleDOI
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.
Alexandre Belot,Paul R. Kasher,Eleanor W. Trotter,Anne Perrine Foray,Anne Laure Debaud,Gillian I. Rice,Marcin Szynkiewicz,Marie Therese Zabot,Isabelle Rouvet,Sanjeev S. Bhaskar,Sarah B. Daly,Jonathan E. Dickerson,Josephine Mayer,James O'Sullivan,Laurent Juillard,Jill E. Urquhart,Shameem Fawdar,Anna A. Marusiak,Natalie Stephenson,Bohdan Waszkowycz,Michael W. Beresford,Leslie G. Biesecker,Graeme C.M. Black,Céline René,Jean Francois Eliaou,Nicole Fabien,Bruno Ranchin,Pierre Cochat,Patrick M. Gaffney,Flore Rozenberg,Pierre Lebon,Christophe Malcus,Yanick J. Crow,John Brognard,Nathalie Bonnefoy +34 more
TL;DR: The findings indicate that PKCδ is crucial in regulating B cell tolerance and preventing self-reactivity in humans, and that PKcδ deficiency represents a novel genetic defect of apoptosis leading to SLE.
Journal ArticleDOI
A paradigm shift in the delivery of services for diagnosis of inherited retinal disease
James O'Sullivan,Brendan G Mullaney,Sanjeev S. Bhaskar,Jonathan E. Dickerson,Georgina Hall,Anna O'Grady,Andrew R. Webster,Simon C Ramsden,Graeme C.M. Black +8 more
TL;DR: The new NGS approach delivers a step change in the diagnosis of inherited eye disease, provides precise diagnostic information and extends the possibility of targeted treatments including gene therapy.