R
Roger Gejman
Researcher at Pontifical Catholic University of Chile
Publications - 21
Citations - 1580
Roger Gejman is an academic researcher from Pontifical Catholic University of Chile. The author has contributed to research in topics: Adenoma & Pituitary adenoma. The author has an hindex of 10, co-authored 21 publications receiving 1449 citations. Previous affiliations of Roger Gejman include Harvard University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Activation of p53 by MEG3 non-coding RNA.
Yunli Zhou,Ying Zhong,Yingying Wang,Xun Zhang,Dalia L. Batista,Roger Gejman,Peter J. Ansell,Jing Zhao,Catherine Weng,Anne Klibanski +9 more
TL;DR: It is found that transfection of expression constructs for MEG3 and its isoforms results in a significant increase in p53 protein levels and dramatically stimulates p 53-dependent transcription from a p53-responsive promoter, supporting the concept that M EG3 functions as a non-coding RNA.
Journal ArticleDOI
Maternally Expressed Gene 3, an Imprinted Noncoding RNA Gene, Is Associated with Meningioma Pathogenesis and Progression
Xun Zhang,Roger Gejman,Ali Mahta,Ying Zhong,Kimberley A. Rice,Yunli Zhou,Pornsuk Cheunsuchon,David N. Louis,Anne Klibanski +8 more
TL;DR: Data are consistent with the hypothesis that MEG3, which encodes a noncoding RNA, may be a tumor suppressor gene at chromosome 14q32 involved in meningioma progression via a novel mechanism.
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The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas.
Dalia L. Batista,Xun Zhang,Roger Gejman,Peter J. Ansell,Yunli Zhou,Sarah A. Johnson,Brooke Swearingen,E. Tessa Hedley-Whyte,Constantine A. Stratakis,Anne Klibanski +9 more
TL;DR: The hypothesis that somatostatin analog pasireotide (SOM230) may have a role in the medical therapy of corticotroph tumors is supported by in vitro results that significantly suppressed cell proliferation and ACTH secretion in primary cultures of human corticOTroph tumors.
Journal ArticleDOI
Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas☆
TL;DR: There was no significant difference between the 2 groups with regard to invasion, suprasellar extension, size, tumor type, postoperative radiotherapy, extent of resection, sex, and age.
Journal ArticleDOI
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase
Sumie Kato,Susan V. Smalley,Anil Sadarangani,K. Chen-Lin,Barbara Oliva,Jorge Brañes,Jorge A Carvajal,Roger Gejman,Gareth I. Owen,Mauricio Cuello +9 more
TL;DR: It is demonstrated that lipophilic but not hydrophilic statins induce cell death through activation of extrinsic and intrinsic apoptotic cascades in cancerous cells from the human female genital tract, which express high levels of HMG‐CoA reductase.