C
Constantine A. Stratakis
Researcher at National Institutes of Health
Publications - 759
Citations - 37973
Constantine A. Stratakis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Carney complex & PRKAR1A. The author has an hindex of 92, co-authored 716 publications receiving 33374 citations. Previous affiliations of Constantine A. Stratakis include Memorial Sloan Kettering Cancer Center & Nuclear Regulatory Commission.
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Journal ArticleDOI
Cushing's syndrome
TL;DR: The current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches, and diagnostic algorithms and recommendations for management of Cushing's syndrome are reviewed.
Journal ArticleDOI
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Wendy Balemans,Martin Ebeling,N Patel,E Van Hul,P Olson,M Dioszegi,C Lacza,Wim Wuyts,J Van den Ende,Patrick Willems,AF Paes-Alves,Suvimol Hill,Manuel Bueno,Feliciano J. Ramos,Paolo Tacconi,Frederik G. Dikkers,Constantine A. Stratakis,Klaus Lindpaintner,B Vickery,Dorothee Foernzler,W. Van Hul +20 more
TL;DR: The SOST gene, which is mutated in sclerosteosis patients, encodes a protein with a signal peptide for secretion and a cysteine-knot motif that might become an important tool in the development of therapeutic strategies for osteoporosis.
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Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex
Lawrence S. Kirschner,J A Carney,Svetlana Pack,Susan E. Taymans,Christoforos Giatzakis,Y S Cho,Yoon S. Cho-Chung,Constantine A. Stratakis +7 more
TL;DR: It is concluded that germline mutations in PRKAR1A, an apparent tumour-suppressor gene, are responsible for the CNC phenotype in a subset of patients with this disease.
Journal ArticleDOI
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
Stefan R. Bornstein,Bruno Allolio,Wiebke Arlt,Andreas Barthel,Andrew C. Don-Wauchope,Gary D. Hammer,Eystein S. Husebye,Deborah P Merke,M. Hassan Murad,Constantine A. Stratakis,David J. Torpy +10 more
TL;DR: A low diagnostic threshold in acutely ill patients, as well as in patients with predisposing factors, is suggested for pregnant women with unexplained persistent nausea, fatigue, and hypotension and a short corticotropin test is recommended as the "gold standard" diagnostic tool to establish the diagnosis.
Journal ArticleDOI
Clinical and Molecular Features of the Carney Complex: Diagnostic Criteria and Recommendations for Patient Evaluation
TL;DR: The clinical manifestations of Carney complex are summarized from a worldwide collection of affected patients and an estimate of penetrance and recommendations for genetic screening are provided.