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Roger Graham Hall
Researcher at Syngenta
Publications - 54
Citations - 1609
Roger Graham Hall is an academic researcher from Syngenta. The author has contributed to research in topics: Tautomer & Alkyl. The author has an hindex of 16, co-authored 54 publications receiving 1563 citations. Previous affiliations of Roger Graham Hall include Novartis & Bayer.
Papers
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Journal ArticleDOI
CGP 35348: a centrally active blocker of GABAB receptors.
H.-R. Olpe,Göril Karlsson,Mario F. Pozza,Felix Brugger,Martin W. Steinmann,H. van Riezen,Graham E. Fagg,Roger Graham Hall,Wolfgang Froestl,Helmut Bittiger +9 more
TL;DR: Ionophoretic and behavioural experiments showed that GABAB receptors in the brain were blocked after i.p. administration of CGP 35348, which appeared to be 10-30 times more potent than the GABAB receptor blocker phaclofen.
Journal ArticleDOI
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
Wolfgang Froestl,Stuart J. Mickel,von Sprecher G,P. J. Diel,Roger Graham Hall,Ludwig Maier,Dietrich Strub,Melillo,P. A. Baumann,Raymond Bernasconi +9 more
TL;DR: In exploring GABA and baclofen derivatives by replacing the carboxylic acid residue with various phosphinic acid groups, more potent and water soluble GABAB antagonists were discovered, suggesting potential cognition enhancing effects.
Journal ArticleDOI
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Wolfgang Froestl,Stuart J. Mickel,Roger Graham Hall,Sprecher Georg Von,Dietrich Strub,P. A. Baumann,Felix Brugger,Conrad Gentsch,Joachim Jaekel +8 more
TL;DR: The syntheses and biological properties of two new series of GABAB agonists, the best compounds of which are more potent than baclofen in vitro and in vivo are described, providing new muscle relaxant drugs with significantly improved side effect profiles.
Journal ArticleDOI
The importance of fluorine in the life science industry
TL;DR: The structures of the fluorine-containing development compounds proposed for ISO common names between 1997 and 2002 are highlighted in this paper and the positive effects of fluorine on the biological efficiency are outlined.
Patent
Spiroheterocyclic n-oxypiperidines as pesticides
Michel Muehlebach,Pitterna Thomas,Cassayre Jerome Yves,Andrew Edmunds,Camilla Corsi,El Qacemi Myriem,Roger Graham Hall,Andr Jeanguenat,André Stoller,Christopher Richard Ayles Godfrey,Jürgen Harry Schaetzer,Loiseleur Olivier,Peter Maienfisch,Neil Brian Carter +13 more
TL;DR: A compound of the formula (I), wherein the substituents are as defined in claim 1, are useful as a pesticides as discussed by the authors, and a compound of I can be used as a pesticide.