R
Roger H Unger
Researcher at United States Department of Veterans Affairs
Publications - 4
Citations - 1188
Roger H Unger is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Insulin & Leptin. The author has an hindex of 3, co-authored 4 publications receiving 1139 citations. Previous affiliations of Roger H Unger include University of Texas at Austin.
Papers
More filters
Journal ArticleDOI
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships
TL;DR: A role for hyperlipacidemia in the pathogenesis of NIDDM is suggested; resistance to insulin-mediated antilipolysis is invoked to explain the high FFA despite hyperinsulinemia, and sensitivity of beta cells to hyperlipacedemia is invokedto explain the FFA-induced loss of GSIS.
Journal ArticleDOI
Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity
TL;DR: In this paper, obesity is associated with both insulin resistance and hyperinsulinemia, which is a condition that compensates for the insulin resistance by maintaining normal glucose homeostasis.
Journal ArticleDOI
β-Cell Function in Normal Rats Made Chronically Hyperleptinemic by Adenovirus-Leptin Gene Therapy
Kazunori Koyama,Guoxun Chen,May-Yun Wang,Young H Lee,Michio Shimabukuro,Christopher B. Newgard,Roger H Unger,Roger H Unger +7 more
TL;DR: It is concluded that in normal rats, hyperleptinemia for 2 weeks causes reversible β-cell dysfunction by depleting tissue lipids, thereby depriving β-cells of a lipid-derived signal required for the insulin response to other fuels.
Patent
Methods for inhibiting βcell apoptosis
TL;DR: In this paper, the active agents for preventing β-cell destruction in obesity related NIDDM are troglitazone, leptin, triacsin and fumosinins, and no-production inhibitors like aminoguanidines.