H
Hiroshi Hirose
Researcher at University of Texas Southwestern Medical Center
Publications - 6
Citations - 1226
Hiroshi Hirose is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Beta cell & Insulin. The author has an hindex of 5, co-authored 6 publications receiving 1169 citations. Previous affiliations of Hiroshi Hirose include Keio University.
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Journal ArticleDOI
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships
TL;DR: A role for hyperlipacidemia in the pathogenesis of NIDDM is suggested; resistance to insulin-mediated antilipolysis is invoked to explain the high FFA despite hyperinsulinemia, and sensitivity of beta cells to hyperlipacedemia is invokedto explain the FFA-induced loss of GSIS.
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Pancreatic β-Cells in Obesity: EVIDENCE FOR INDUCTION OF FUNCTIONAL, MORPHOLOGIC, AND METABOLIC ABNORMALITIES BY INCREASED LONG CHAIN FATTY ACIDS (∗)
Joseph L. Milburn,Hiroshi Hirose,Young H Lee,Yoshitaka Nagasawa,Atsushi Ogawa,M. Ohneda,Hector BeltrandelRio,Christopher B. Newgard,John H. Johnson,John H. Johnson,Roger H Unger,Roger H Unger +11 more
TL;DR: It is concluded that hypersecretion of insulin by islets of obese Zucker fatty rats is associated with, and probably caused by, enhanced low Km glucose metabolism and beta-cell hyperplasia, abnormalities that can be induced in normal islets by increased FFA.
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Defective Fatty Acid-mediated β-Cell Compensation in Zucker Diabetic Fatty Rats: PATHOGENIC IMPLICATIONS FOR OBESITY-DEPENDENT DIABETES (∗)
Hiroshi Hirose,Young H Lee,Lindsey R. Inman,Lindsey R. Inman,Yoshitaka Nagasawa,John H. Johnson,Roger H Unger +6 more
TL;DR: In this paper, islets from 6-week-old obese (fa/fa) rats that had compensated for obesity were cultured in 0, 1, or 2 mM FFA.
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"Low dose" metformin improves hyperglycemia better than acarbose in type 2 diabetics.
TL;DR: "low dose" metformin therapy improved glycemic control better than acarbose in non-obese diabetics, and significantly decreased HbA1c levels as compared to acarbOSE.
Journal ArticleDOI
Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas
Katsuhiko Ito,Hiroshi Hirose,Hiroshi Hirose,Koichi Kido,Kazunori Koyama,Hiroshi Maruyama,Takao Saruta +6 more
TL;DR: The data do not, however, provide evidence indicating that glucopenia-induced glucagon secretion is mainly mediated by activation of sympathetic nerve terminals around the alpha-cells in the isolated perfused rat pancreas.