R
Roger J. P. Dawson
Researcher at ETH Zurich
Publications - 8
Citations - 2574
Roger J. P. Dawson is an academic researcher from ETH Zurich. The author has contributed to research in topics: ATP-binding cassette transporter & ATP-binding domain of ABC transporters. The author has an hindex of 6, co-authored 7 publications receiving 2451 citations.
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Structure of a bacterial multidrug ABC transporter
TL;DR: The observed, outward-facing conformation reflects the ATP-bound state, with the two nucleotide-binding domains in close contact and the two transmembrane domains forming a central cavity—presumably the drug translocation pathway—that is shielded from the inner leaflet of the lipid bilayer and from the cytoplasm, but exposed to the outer leaflet and the extracellular space.
Journal ArticleDOI
Structure and mechanism of ABC transporter proteins
TL;DR: The crystal structures of four ABC transporters reveal a mechanism that rationalizes ATP-driven transport: While binding of ATP appears to trigger an outward-facing conformation, dissociation of the hydrolysis products may promote an inward- facing conformation.
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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP‐PNP
TL;DR: The crystal structure of Sav1866 in complex with adenosine‐5′‐(β,γ‐imido)triphosphate (AMP‐PNP) at 3.4 Å resolution confirms that the ATP‐bound state of multidrug ABC transporters is coupled to an outward‐facing conformation of the transmembrane domains.
ComponentDOI
Structure of the mu-opioid receptor-Giprotein complex.
Antoine Koehl,Hongli Hu,Shoji Maeda,Yan Zhang,Qianhui Qu,Joseph M. Paggi,Naomi R. Latorraca,Daniel Hilger,Roger J. P. Dawson,Hugues Matile,Gebhard F. X. Schertler,Sébastien Granier,William I. Weis,Ron O. Dror,Aashish Manglik,Georgios Skiniotis,Brian K. Kobilka +16 more
Journal ArticleDOI
Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism.
TL;DR: The recent crystal structures of four complete ABC transporters suggest that a key step of the molecular mechanism is conserved in importers and exporters, and can in principle explain ATP‐driven drug export and binding protein‐dependent nutrient uptake.